碘佛醇造影剂在螺旋CT扫描结合内镜检查恶性肿瘤的临床应用价值  

Clinical application of iodiol contrast agent in malignant tumor by spiral CT scanning combined with endoscopy

作　　者：兰俊[1] 何伟莉[1] 林黎明[1] 邹建勋[1] 王明杰[1] 林言[2] 

机构地区：[1]丽水市人民医院放射科,浙江丽水323000 [2]宁波市第二医院放射科,浙江宁波315000

出　　处：《中国生化药物杂志》2017年第3期291-293,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省卫生厅科技计划(2013KYB237)

摘　　要：目的 研究碘佛醇造影剂在螺旋CT扫描结合内镜检查恶性肿瘤的临床应用价值。方法 选取100例经病理学证实的恶性肿瘤患者,并随机分为2组。实验组（n=50）采用用碘佛醇造影剂配合螺旋CT扫描结合内镜检查,碘佛醇在37℃时的渗透压力为600 m Osm/kg,在注射之前5 min静脉推入10 mg的预防用药地塞米松,然后进行螺旋CT机扫描。对照组（n=50）采用泛影葡胺造影剂配合螺旋CT扫描结合内镜检查,泛影葡胺在37℃时的渗透压力为1500 m Osm/kg,在注射之前5 min静脉推入10 mg的预防用药地塞米松,然后进行螺旋CT机扫描。结果 实验组不良反应的发生率为4%,对照组不良反应的发生率为12%,实验组不良反应情况显著轻于对照组（P〈0.05）。实验组患者的耐受性和螺旋CT影像质量显著优于对照组,2组比较差异有统计学意义（P〈0.05）。结论 碘佛醇造影剂不论是不良反应还是影像质量都比泛影葡胺造影剂效果好,在螺旋CT扫描结合内镜检查恶性肿瘤患者临床的应用价值较高,可以更精确地诊断恶性肿瘤。Objective To evaluate the clinical value of iohexol contrast agent in patients with malignant tumor by spiral CT scan combined with endoscopy.Methods 100 patients with pathologically confirmed malignancies were selected and randomly divided into two groups, with 50 cases in each group, the experimental group received iodohexanol contrast agent combined with spiral CT scan and endoscopy , the osmotic pressure of iohexol at 37℃600 mOsm/kg, 5 minutes before the injection of intravenous injection of 10 mg prophylaxis of dexamethasone, and then spiral CT scan was performed.The control group were treated with diatrizoate contrast agent combined with spiral CT scan and endoscopy.The osmotic pressure of diatrizoate was 1500 mOsm/kg at 37℃, and 10 mg of prophylactic drug dexamethasone was injected intravenously 5 minutes before the injection.And then a spiral CT scan was performed.Results The adverse reaction in experimental group was 4%, which was mild compared with 12% in control group （ P〈0.05 ） .The tolerance and spiral CT image quality of experimental group were better than those of control group （ P〈0.05 ） .Conclusion Iohexol contrast agent, whether adverse reaction or image quality than the effect of diatrizoate contrast agent , in the spiral CT scan combined with endoscopy in patients with malignant tumors of higher clinical value, can be more accurate diagnosis of malignant tumors.

关 键 词：碘佛醇 泛影葡胺 螺旋CT 恶性肿瘤 不良反应 

分 类 号：R730.4[医药卫生—肿瘤]