泌乳素与淋巴细胞亚群对精神分裂症患者免疫相关指标影响的初步研究  

Preliminary study about effect of prolactin and lymphocyte subsets on immune related indexes in patients with schizophrenia

作　　者：李丹[1] 朱莉莉[1] 高琼[1] 胥杰[1] 林萍[1] 

机构地区：[1]上海市精神卫生中心检验科,200030

出　　处：《国际检验医学杂志》2017年第6期723-724,728,共3页International Journal of Laboratory Medicine

基　　金：吴阶平医学基金会临床科研专项资助基金(320675015232)

摘　　要：目的通过分析淋巴细胞亚群和免疫球蛋白(IgG、IgM、IgA)水平变化,初步探讨精神分裂症患者体内高浓度泌乳素对免疫系统的影响。方法流式细胞仪分别检测T淋巴细胞CD3^+、CD4^+、CD8^+亚群、NK细胞百分比以及CD4^+/CD8^+比值;应用免疫速率散射比浊法检测外周血体液免疫3项(IgG、IgM、IgA)。采用方差分析对数据进行统计分析。结果与健康对照组和精神分裂症泌乳素正常组比较,精神分裂症泌乳素增高组的T淋巴细胞CD4^+亚群百分比、CD4^+/CD8^+比值及IgG水平增高(P<0.05);而精神分裂症泌乳素增高组的NK细胞百分比降低(P<0.05)。结论高浓度的泌乳素可能通过影响淋巴细胞亚群之间的平衡以及免疫球蛋白的产生而对免疫系统产生一定的影响。Objective To preliminarily study the effect of high concentration prolactin（PRL）on the immune system in schizophrenic patients by analyzing the changes of lymphocyte subsets and immunoglobulins（IgG,IgM,IgA）levels.Methods The flow cytometry was used to detect the T lymphocytes CD3^＋,CD4^＋and CD8^＋subsets,NK cell percentages and CD4^＋/CD8^＋ ratio respectively.The three humoral immune indicators（IgG,IgM,IgA）in peripheral blood were detected by using the immunoturbidimetric turbidimetric method.The data were analyzed by adopting the analysis of variance.Results Compared with the healthy control group and schizophrenia normal PRL group,T lymphocytes CD4^＋subsets percentages and CD4^＋/CD8^＋ ratio as well as IgG were increased in the schizophrenia PRL increase group（P〈0.05）,while the percentage of NK cells was decreased（P〈0.05）.Conclusion High concentration PRL may have a certain effect on the immune system by influencing the balance among lymphocyte subsets and the production of immunoglobulins.

关 键 词：精神分裂症 泌乳素 淋巴细胞亚群 免疫球蛋白 

分 类 号：R749.3[医药卫生—神经病学与精神病学]