非霍奇金淋巴瘤患者血清可溶性白细胞介素-2受体检测及意义  

Detection of serum soluble interleukin-2 receptor in patients with non-Hodgkin lymphoma and its clinical significance

作　　者：顾科峰[1,2] 陆静忠 宋超英[1] 

机构地区：[1]上海交通大学附属新华医院崇明分院内科,上海202150 [2]上海市虹口区广中路街道社区卫生服务中心全科,200083

出　　处：《国际检验医学杂志》2017年第6期777-780,共4页International Journal of Laboratory Medicine

基　　金：上海交通大学医学院附属新华医院崇明分院科研基金项目(Q201311)

摘　　要：目的探讨非霍奇金淋巴瘤(NHL)患者化疗前后血清可溶性白细胞介素-2受体(sIL-2R)水平的变化及临床意义。方法采用双抗体夹心酶联免疫吸附测定,动态监测40例NHL及10例淋巴瘤相关性噬血细胞综合征(LAHS)患者初治、化疗后血清sIL-2R的水平。根据患者治疗的效果分为完全缓解、缓解后复发以及未缓解组并进行比较。结果 NHL患者初治组、缓解后复发组、化疗后未缓解组以及LAHS组sIL-2R表达水平显著高于对照组和化疗后缓解组(P<0.05),而NHL化疗后完全缓解组与对照组比较,差异无统计学意义(P>0.05)。动态监测治疗前后sIL-2R表达水平变化与国际预后指数(IPI)、铁蛋白等均呈正相关关系(P<0.05)。结论 NHL患者细胞免疫功能低下,并且与疾病的恶性程度有关,化疗有效的患者细胞免疫功能得到明显改善。通过对NHL患者血清sIL-2R表达水平监测有利于NHL复发早期诊断,并可判断其化疗疗效及预后。Objective To explore the change and clinical significance of serum soluble interleukin-2receptor（sIL-2R）before and after chemotherapy in the patients with non-Hodgkin lymphoma（NHL）.Methods The double antibody sandwich enzyme-linked immunosorbent assay was adopted to dynamically monitor the sIL-2Rexpression levels in different groups of initial treatment,complete remission after chemotherapy,relapse after remission and non-remission after chemotherapy among 40 patients with HNL and10 patients with lymphoma-associated hemophagocytic syndrome.Results The expression level of sIL-2Rin the NHL patients groups of initial treatment,relapse after remission group,non-remission after chemotherapy and LAHS was significantly higher than that in the normal control group and the patients group of complete remission after chemotherapy,while the difference between the NHL patients group of complete remission after chemotherapy and the normal control group had no statistical significance（P〉0.05）.The sIL-2Rexpression level change in dynamic monitoring before and after treatment was positively correlated with the international prognostic index（IPI）and ferritin（P〈0.05）.Conclusion NHL patients have cellular immune hypofunction,which is related to the malignant degree of disease,the cellular immune function in the patients with chemotherapeutic effect obtains significant improvement.Monitoring the serum sIL-2Rexpression level in the patients with NHL is helpful to early diagnosing recrudescent NHL and assess the chemotherapeutic effect and prognosis.

关 键 词：非霍奇金淋巴瘤 淋巴瘤相关性噬血细胞综合征 可溶性白细胞介素2受体 

分 类 号：R733.1[医药卫生—肿瘤]