老年首发未经治疗精神分裂症患者肠道菌群的变化  

Changes of intestinal floras in elderly patients with first-episode untreated schizophrenia

作　　者：李永生[1] 卢燕金 陈家强[1] 谢筱颖[1] 伍华林[1] 

机构地区：[1]佛山市第三人民医院检验科,广东528000 [2]佛山市南海区第五人民医院西药房,广东528211

出　　处：《国际检验医学杂志》2017年第6期808-809,共2页International Journal of Laboratory Medicine

基　　金：佛山市卫生和计生局医学科研课题(20170134)

摘　　要：目的观察老年首发未经治疗的精神分裂症患者肠道菌群的变化,分析肠道菌群在精神分裂症中扮演的角色。方法选取30例2016年7月至2016年10月就诊于精神科的老年(≥60岁)首发未经治疗的精神分裂症患者作为观察组,30例同期体检的健康人作为对照组,采用16SrRNA实时荧光定量PCR(qPCR)检测对两组大便标本中的双歧杆菌属、乳酸杆菌属、拟杆菌属进行绝对定量。结果观察组粪便中双歧杆菌水平明显低于对照组,拟杆菌水平明显高于对照组,且肠道拟杆菌/乳酸杆菌与拟杆菌/双歧杆菌的比值明显升高,差异均有统计学意义(P<0.05);两组的乳酸杆菌水平比较差异无统计学意义(P>0.05)。结论老年首发未经治疗的精神分裂症患者存在肠道菌群的紊乱、肠道菌群比例失调等现象,肠道菌群可能参与了精神分裂症的发病。Objective To investigate the changes of intestinal floras in elderly patients with first-episode untreated schizophrenia and to analyze the role of intestinal floras in schizophrenia.Methods Thirty elderly patients（≥60years old）with first-episode untreated schizophrenia treated in our hospital from July to October 2016 were selected as the observation group,while 30 healthy people undergoing physical examination in the same period were selected as the control group.The bifidobacterium,lactobacillus and bacteroides of stool samples in the two groups were tested by 16 SrRNA real-time fluorescence quantitative PCR（qPCR）.ResultsThe bifidobacterium content of stool samples in the observation group was significantly lower than that in the control group,while the bacteroides content was significantly higher than that in the control group,moreover the ratios of bacteroides/lactobacillus and bacteroides/bifidobacterium in the observation group were significantly increased,the difference was statistically significant（P〈0.05）;the lactobacillus content had no obvious difference between the two groups.Conclusion The phenomena of intestinal flora disorder and intestinal flora disproportion exist in elderly patients with first-episode untreated schizophrenia.Intestinal flora may be involved in the pathogenesis of schizophrenia.

关 键 词：肠道菌群 精神分裂症 首发 老年 

分 类 号：R749.3[医药卫生—神经病学与精神病学]