Syntenin在非小细胞肺癌中的表达及其与患者总生存期的关系  

Expression of Syntenin in non-small cell lung cancer tissues and its relationship with overall survival of patients

作　　者：宋杰[1] 李萍[1] 于雪新 冯林[1] 高燕宁[1] 肖汀[1] 

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院分子肿瘤学国家重点实验室癌发生及预防分子机理北京市重点实验室,北京100021

出　　处：《癌变．畸变．突变》2017年第2期102-105,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：协和青年基金(3332016032)

摘　　要：目的:检测Syntenin在非小细胞肺癌(NSCLC)组织中的蛋白表达水平并探讨其临床意义。方法:采用组织芯片和免疫组织化学染色法,检测Syntenin在147例NSCLC及相应癌旁组织中的表达水平,并分析Syntenin的表达与NSCLC患者临床病理指标及预后的关系。结果:Syntenin在NSCLC组织中的阳性表达率(49.7%)显著高于癌旁组织(4.1%)(P<0.01)。Syntenin的表达与NSCLC的淋巴结转移、临床分期和病理类型显著相关(P值分别为0.039、0.038、0.024),与患者的性别和年龄无显著相关(P>0.05)。Kaplan-Meier分析表明,Syntenin的表达与NSCLC患者的总生存期显著相关(P=0.028)。结论:Syntenin在NSCLC组织中高表达,并且其高表达预示了患者的不良预后。OBJECTIVE：The aim of this study was to detect the expression of Syntenin in non-small cell lung cancer （NSCLC） tissues and to explore its clinical significance.METHODS：We detected expression of Syntenin in 147 NSCLC tissues and 147 para-carcinoma tissues by tissue microarray and immunohistochemical staining method,and analyzed the relationship of Syntenin expression with clinicopathological parameters and prognosis of NSCLC patients. RESULTS：Expression level of Syntenin （positive rate 49.7%） in NSCLC tissues was significantly higher than that in adjacent lung tissues （positive rate 4.1%,P〈0.01）. Over-expression of Syntenin was associated with lymph node metastasis,clinical stage and pathological type in NSCLC patients （P=0.039,P=0.038 andP=0.024）,but not with age or gender. The Kaplan-Meier survival analysis revealed that Syntenin expression in primary tumors was significantly associated with patients＇ overall survival （P=0.028）. CONCLUSION：Syntenin protein was over-expressed in NSCLC tissues,and was associated with poor prognosis of patients.

关 键 词：SYNTENIN 非小细胞肺癌 淋巴结转移 总生存期 

分 类 号：R730.2[医药卫生—肿瘤]