凝血酶原片段1＋2与宫颈癌经外周静脉穿刺中心静脉置管患者静脉血栓形成的研究  

The relationship between prothrombin fragment 1＋2 and peripherally inserted central catheter ;associated thrombosis in cervical cancer patients

作　　者：原娜[1] 焦英华[1] 王喆[1] 龚欢欢[1] 卢秀荣[1] 张贤雨[1] 马欢[1] 李锦秋[1] 张志林[1] 

机构地区：[1]河北北方学院附属第一医院放疗科,张家口075000

出　　处：《中国医师进修杂志》2017年第2期111-114,共4页Chinese Journal of Postgraduates of Medicine

基　　金：张家口市科学技术和地震局科学技术与发展计划自筹经费项目（1421129D）

摘　　要：目的：分析凝血酶原片段1＋2（F1＋2）在宫颈癌经外周静脉穿刺中心静脉置管（PICC）患者静脉血栓中的变化，为宫颈癌PICC患者静脉血栓形成早期预防提供一定的参考依据。方法选取符合PICC要求的140例宫颈癌患者，根据是否有PICC相关性血栓形成，分为血栓组（35例）和无血栓组（105例），采用酶联免疫法检测F1＋2水平，结合临床特征进行分析。结果 F1＋2水平与宫颈癌国际妇产科联盟（FIGO）分期有相关性（r=0.640，P=0.004）；与年龄、细胞类型、同步放化疗方式无相关性（P＞0.05）。血栓组F1＋2水平为（520.343±121.759）pmol/L，无血栓组为（388.361±104.873）pmol/L，两组比较差异有统计学意义（P=0.001）。多因素Logistic回归分析结果显示，F1＋2水平（OR=1.011，P=0.001）、年龄（OR=21.025，P=0.031）是宫颈癌PICC患者静脉血栓形成的独立危险因素。结论 F1＋2与宫颈癌临床分期、PICC静脉血栓形成有密切联系，是宫颈癌PICC静脉血栓的独立危险因素。Objective To investigate the relationship between prothrombin fragment 1＋2 （F1＋2） and peripherally inserted central catheter （PICC） associated thrombosis in cervical cancer patients, and provide certain clinical basis of early prevention in peripherally inserted central catheter associated thrombosis in cervical cancer patients. Methods One hundred and forty cervical patients with PICC were enrolled in this study, and they were divided into thrombosis group （35 patients） and non-thrombosis group （105 patients）. The level of F1＋2 was examined using enzyme-linked immunoassay, and was analyzed according to the clinic features. Results The level of F1＋2 was correlated with clinical stage （r = 0.640, P = 0.004）;but was not correlated with age, type of tumor and concurrent radiochemotherapy （P〉0.05）. The level of F1＋2 in thrombosis group was （520.343 ± 121.759） pmol/L, in non- thrombosis group was （388.361 ± 104.873） pmol/L, and there was significant difference （P =0.001）. The multi-factors Logistic analysis showed that the level of F1＋2 （OR=1.011, P=0.001） and age （OR = 21.025, P = 0.031） were independent risk factors for the PICC associated with thrombosis in cervical cancer. Conclusions The level of F1＋2 is closely related with clinical stage and PICC associated thrombosis, and it is an independent risk factor for the PICC associated with thrombosis in cervical cancer.

关 键 词：宫颈肿瘤 经外周静脉穿刺中心静脉置管 导管相关性静脉血栓 凝血酶原片段1+2 

分 类 号：R737.33[医药卫生—肿瘤]