高度近视患者玻璃体中MMP-2和TGF-β2水平与眼轴的相关性（英文）  

Relationship of MMP-2 or TGF-β2 levels in human vitreous with axial length

作　　者：赵婷婷[1] 吴梦竹[1] 靳婧[1] 谢书浓 樊莹[1] 

机构地区：[1]中国上海市上海交通大学附属第一人民医院眼科,200080

出　　处：《国际眼科杂志》2017年第4期587-591,共5页International Eye Science

基　　金：Major State Basic Research Development Program of China(No.2011CB707500)~~

摘　　要：目的:探究高度近视患者眼轴与玻璃体中MMP-2和TGF-β2水平的相关性。方法:研究患者玻璃体切除术中获取玻璃体样本55份。依据角膜表面曲率大小及眼轴长度,将研究对象分为两组:即高度近视组(25例):SE>-6.00D,AL≥26.00mm和对照组或非高度近视组(30例):SE≤-6.00D,AL<26.00mm。利用ELISA的方法测量研究对象玻璃体MMP-2和TGF-β2浓度。结果:高度近视组玻璃体MMP-2浓度(96.87±55.95ng/mL)显著高于对照组(77.24±41.81ng/mL,P<0.05),但与眼轴没有相关性(r=0.088,P=0.544)。高度近视组(3729.08±1890.88pg/mL)与对照组(3926.00±1333.88pg/mL,P<0.05)TGF-β2浓度具有显著差异性,且TGF-β2浓度与眼轴长度呈负相关(r=-0.344,P=0.014)。结论:人玻璃体中MMP-2和TGF-β2两种分子浓度在高度近视进展中具有重要作用,TGF-β2浓度与眼轴长度具有相关性。·AIM： To investigate the relationship of matrix metalloproteinase-2 （ MMP-2 ） and transforming growth factor-beta 2 （ TGF-β2 ） levels in human vitreous with axial length （ AL） of patients with high myopia.·METHODS：The concentrations of MMP-2 and TGF-β2 levels were tested by Enzyme-Linked Immunosorbnent Assay （ELISA）. Fifty-five human vitreous samples of 55 patients were collected during vitrectomy surgery, and were divided into two groups according to their spherical equivalent （ SE ） and axial length （ AL ） . High myopia group （ 25 cases ）： SE〉-6. 00D, AL≥26. 00mm, and control group or non-high myopia group （30 cases）： SE〈-6. 00D, A≥26. 00mm. ·RESULTS：The MMP-2 levels in vitreous of high myopia group （96. 87±55. 95ng/mL） was significantly higher than that of control group （77. 24±41. 81ng/mL, P〈0. 05）, but not correlated with AL （r=0. 088, P=0. 544）. While the TGF-β2 vitreous concentration was negatively correlated with AL （r=-0. 344, P=0. 014）, and there was significant difference of TGF-β2 vitreous levels between high myopia group （ 3729. 08 ± 1890. 88pg/mL ） and control group （3926. 00±1333. 88pg/mL, P〈0. 05）. ·CONCLUSION：MMP-2 and TGF-β2 in human vitreous may play a critical role in human high myopia development, and the TGF-β2 appears to be associated with axial length.

关 键 词：基质金属蛋白酶-2 转移生长因子-β2 玻璃体 高度近视 眼轴长度 

分 类 号：R778.11[医药卫生—眼科]