高龄老人肱-踝脉搏波传导速度与MMSE评分相关性研究  

Clinical study on correlation of brachial-ankle pulse wave velocity with MMSE score in senile people

作　　者：杨翔[1] 杨春[2] 张瑗[1] 刘瑜[1] 吴宁[1] 万文辉[1] 钱晓明[1] 

机构地区：[1]南京大学附属金陵医院(南京军区南京总医院)干部一科,南京210002 [2]南京大学附属金陵医院(南京军区南京总医院)干部心内科,南京210002

出　　处：《东南国防医药》2017年第1期20-24,共5页Military Medical Journal of Southeast China

基　　金：全军保健专项科研课题(13BJZ11);南京军区南京总医院院管课题(2014065)

摘　　要：目的研究高龄老人(≥80岁)肱-踝脉搏波传导速度(brachical-ankle pulse wave velocity,ba-PWV)在评价认知功能障碍的临床价值,探讨高龄老人认知功能障碍患者与ba-PWV的相关性。方法共选取187例80岁以上高龄老年人纳入研究,对符合研究标准的患者进行ba-PWV的测量、病史采集及常规实验室指标检查,采用简易精神状态检查量表(MMSE)评估患者认知功能,主要观察MMSE与ba-PWV及各项临床指标的相关性。结果 MMSE>20分组ba-PWV为(1481.0±213.9)cm/s,较MMSE≤20分组[(1886.2±267.9)cm/s]明显降低(P<0.05),MMSE与ba-PWV存在相关性(r=-0.004,P<0.05)。结论认知功能障碍的高龄老人存在肱-踝脉搏波传导速度增加,这可能与动脉硬化引起的靶器官损害有关。Objective To explore the clinical value in the evaluation of cog/nitive dysfunction and to investigate the correlation between senile people who have cognitive dysfunction with ba-PWV （braehial-ankle pulse wave velocity, ba-PWV）. Methods A to- tal of 187 cases selected Senile were included in the study, and patients met the study criteria were taken by ba-PWV measurement. History taking and examination of routine laboratory parameters and MMSE （Minimum Mental State Examination, MMSE） was used to assess cognitive function in patients, and the correlation between MMSE score with ba-PWV was observed. Results The ba-PWV between the group of MMSE in which score was more than 20 [ ba-PWV = （1481.0±213.9） cm/s] and the group of MMSE in which score was less than or equal to 20 [ba-PWV= （1886.2±267.9） cm/s] was significant different （P〈0.05）, and MMSE score and ba- PWV were correlated （r=-0.004,P〈0.05）. Conclusion Ba-PWV can predict the cognitive disfunction of senile people, which may be associated with target organ damages caused by atherosclerosis.

关 键 词：肱-踝脉搏波传导速度 高龄老人 MMSE评分 认知功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]