载脂蛋白H基因多态性与卒中后抑郁的相关性研究  

Relationship between Apolipoprotein H(ApoH)and post-stroke Depression

作　　者：李静[1] 刘杰[1] 王静[2] 宋景贵[3] Li Jing Liu Jie Wang Jing Song Jinggui(Department of Neurology ,the Third People＇s Hospital of Xinxiang Medical College ,Xinxiang 453003 ,Chin)

机构地区：[1]新乡医学院第三附属医院神经内科,新乡453003 [2]新乡医学院第三附属医院CCU,新乡453003 [3]新乡医学院第一附属医院神经内科,卫辉453100

出　　处：《中国实用神经疾病杂志》2017年第7期12-15,共4页Chinese Journal of Practical Nervous Diseases

基　　金：河南省卫生厅医学科技攻关项目(200803083)

摘　　要：目的探讨载脂蛋白H(ApoH)外显子3基因多态性与卒中后患者发生抑郁(PSD)的相关性。方法应用PCR-单链构象多态性分析技术方法进行检测160例脑卒中患者(40例卒中后抑郁患者和120例单纯卒中患者)和100名健康对照者的ApoH基因3号外显子G341A(Ser88Asn)位点的SNP。结果卒中后抑郁组事件相关电位(ERP)测定N2及P3波潜伏期较卒中组和对照组延长(FN2=152.516,P=0.000;FP3=51.186,P=0.000)。P3波幅降低(FP3波幅=40.633,P=0.000)。PSD组血清ApoH水平高于对照组和非抑郁组,差异有统计学意义(P均<0.05)。脑卒中组ApoH基因第3外显子基因多态性与对照组比较差异有统计学意义(P均<0.05),但PSD组与非抑郁组比较差异无统计学意义(P>0.05)。结论 G341A(Ser88Asn)多态性可作为卒中危险因素参考指标,但与PSD发生无明显关系。Objective To investigate the relationship between apolipoprotein H（ApoH）polymorphism in exon3 and poststroke depression.Methods G341A（Ser88Asn）polymorphism in ApoH gene was determined by PCR-single strand conformation plymorphism analysis and DNA sequencing in 100 healthy controls,160 patients with stroke（40patients with post stroke depression and 120 cases of patients without depression）.Results Compared with brain stroke group and control group,latency in ERP including N2 and P3 of PSD group has prolonged（F（N2）=152.516,P=0.000;F（P3）=51.186,P=0.000）,the amplitude of P3 in PSD was lower（FP3=40.633,P=0.000）.ApoH level in PSD group was higher than the control group and the group without depression,the difference was statistically significant（P〈0.05）.Statistically significant differences in exon3 polymorphism were found between the controls and stroke patients.But no statistically significant difference（P〉0.05）were found between the PSD group and the non-depression group（P〉0.05）.Conclusion G341A（Ser88Asn）polymorphism polymorphism can be used as a risk factors in stroke.But there is no close relation between polymorphism of the apolipoprotein H exon3 and PSD.

关 键 词：载脂蛋白H 多态性 卒中后抑郁 

分 类 号：R749.13[医药卫生—神经病学与精神病学]