香豆素类化合物的抑菌活性研究进展  

Advances in Antimicrobial Activity of Coumarins

作　　者：高立东[1] 朱惠泽 赵莹[1] 吕鹤书[1] 柳春梅[1] 

机构地区：[1]北京农学院生物科学与工程学院,北京102206

出　　处：《生物技术进展》2017年第2期116-120,共5页Current Biotechnology

基　　金：国家自然科学基金项目(31300620);北京农学院校级专项经费(BJNXYTW20160412)资助

摘　　要：香豆素类化合物是广泛分布于伞形科等多种高等植物以及微生物代谢产物中的次级代谢产物,生物活性因香豆素母体骨架上取代基团及取代位置不同而多变,具有调节植物生长、抗菌抗病毒、抗凝血、松弛平滑肌、吸收紫外线和抗辐射等多种生物活性。重点综述了近十年来简单香豆素、呋喃香豆素、吡喃香豆素以及合成和天然分离得到的其他香豆素在抑制细菌和植物病原真菌活性方面的研究进展,以期为香豆素类化合物在抑菌方面的开发利用提供科学依据。Coumarin compounds are widely distributed in a variety of higher plants and microbial metabolites, which have shown antibacterial, antiviral, anti-coagulation, smooth muscle relaxation, ultraviolet absorption and anti-radiationactivities. Over the past ten years, there has been a growing interest in antimicrobial activity of the natural and synthetic coumarins. The paper summerized the research on coumarins from recent years, reviewed the documents on structure and antimicrobial activities of coumarin, which was expected to lay the foundation for their development and clinical rational application.

关 键 词：香豆素 结构 抑菌活性 研究进展 

分 类 号：R285[医药卫生—中药学]