天然中药单体及衍生物调控非小细胞肺癌自噬的研究新进展  

Advances in the Research of the Regulation of Chinese Traditional Medicine Monomer and Its Derivatives on Autophagy in Non-small Cell Lung Cancer

作　　者：相美亦 李瑞蕾[1] 张志伟[1] 宋鑫[1] 

机构地区：[1]云南省昆明医科大学第三附属医院,云南省肿瘤医院生物治疗中心,昆明650500

出　　处：《中国肺癌杂志》2017年第3期205-212,共8页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金(No.U1502222;No.81470005;No.81260307);2013-2014年度国家临床重点专科建设项目(云南省肿瘤医院肿瘤科);云南省科技厅应用基础研究项目(No.2015FB074;No.2014FB065;No.2014FB064)资助~~

摘　　要：非小细胞肺癌(non-small cell lung cancer,NSCLC)发病率、病死率高,亟待研发高抗癌活性、低毒副作用的新型疗法。自噬既可诱发NSCLC癌细胞死亡又可介导死亡逃避,多样化的角色使之成为抗癌的新机制。天然中药众多活性单体及其衍生物具备抗NSCLC的活性,甚至可影响其获得性耐药,而对自噬的调控多被证实为其潜在的作用机制。针对多种天然药物来源的萜类化合物、生物碱、膳食多酚、皂苷类化合物及其它活性成分的研究证实,不同单体成分既可影响NSCLC保护性自噬水平,亦可调控其死亡性自噬活性,相应的影响NSCLC的生长及对某些药物的反应性。因而,本文就天然中药成分及其衍生物通过双向调节自噬活性参与NSCLC治疗的最新进展做一综述。The high morbidity and mortality of non-small cell lung cancer（NSCLC） did influence the quality of life of tumor patients world-wide. There is an urgent need to develop new therapies that have high anti-tumor activity and low toxicity side effects. It is widely accepted that autophagy can play diverse roles in carcinogenesis,such as induces pro-death of lung cancer cells or helps the escape from cell death,making it become a proper anticancer target. It＇s believed that various monomers of Chinese traditional medicine closely correlates to anti-NSCLC activities,and that even could affect the acquired multiple drug resistance（MDR）. Furthermore,autophagy might be the underling mechanisms which could play a role as the candidate targets of natural active compounds. Recent studies of terpenoids,alkaloid,dietary polyphenols,saponins and other active ingredients that extracted from a large variety of herbs suggest that different monomer compounds could either regulate the activity of pro-death autophagy or influence the level of protective autophagy of NSCLC cells,thus changing their drug sensitivity and cell viability. This paper aims to give a systemic description of the latest advances about natural compounds and their derivatives that involved in tumorigenesis of NSCLC via inducing the autophagy.

关 键 词：肺肿瘤 中药提取物 自噬 耐药 

分 类 号：R734.2[医药卫生—肿瘤]