自然杀伤细胞对肝星状细胞的调控及其在肝纤维化中的作用  

Regulatory effect of natural killer cells on hepatic stellate cells and their role in liver fibrosis

作　　者：李天阳[1] 涂正坤[1] 苏立山[1] LI Tianyang TU Zhengkun SU Lishan.(Research Institute of Translational Medicine, The First Hospital of Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学第一医院转化医学研究院,长春130021

出　　处：《临床肝胆病杂志》2017年第3期558-562,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81373143;81571535)

摘　　要：肝星状细胞(HSC)的激活与肝纤维化进展有至关重要的联系。作为固有免疫的重要组分,自然杀伤细胞(NK细胞)在肝内的富集程度更高,在机体防御病毒感染和肿瘤中发挥关键作用,而且其抗肝纤维化的功能也得到证实。NK细胞可以通过直接杀伤早期激活或衰老的HSC,或通过分泌IFNγ抑制肝纤维化。总结了最近几年的相关研究进展,以NK细胞和HSC的功能与表型为基础,介绍了NK细胞调控HSC的分子免疫学机制及其潜在的抗肝纤维化作用。Hepatic stellate cell（HSC） activation is closely associated with the progression of liver fibrosis.As an important component of the innate immune system,natural killer（NK） cells are enriched in the liver and play a key role in host defense against viral infection and tumor,and their anti-fibrotic effect has also been confirmed.NK cells can reduce liver fibrosis by killing early-activated or senescent HSCs or secreting interferon-γ.This article summarizes related research advances in recent years,and introduces the molecular immunological mechanism of NK cells in regulating HSCs and their potential anti-fibrotic effect based on the function and phenotype of NK cells and HSCs.

关 键 词：肝硬化 杀伤细胞 天然 肝星状细胞 综述 

分 类 号：R575.2[医药卫生—消化系统]