普罗布考联合阿司匹林溶解治疗颈动脉斑块脑梗死的临床效果观察  

A Study on the Clinical Effect of Probucol combined with Aspirin on Patients with Carotid Plaque Cerebral Infarction

作　　者：张建强 高红安 宋程光 曹群 李莉 曲茂兴[2] 

机构地区：[1]辽宁省本溪市中心医院神经内科,辽宁本溪117000 [2]大连医科大学附属第二医院重症医学科病房,辽宁大连116044

出　　处：《现代生物医学进展》2017年第5期919-922,共4页Progress in Modern Biomedicine

基　　金：辽宁省自然科学基金项目(20140230)

摘　　要：目的:探讨普罗布考联合司匹林溶解治疗颈动脉斑块脑梗死的临床效果。方法:选取于我院进行治疗的颈动脉斑块脑梗死患者60例,根据电脑生成的随机数字表将所有患者随机分为实验组与对照组,每组各30例,对照组患者予以常规治疗及阿司匹林,实验组患者在对照组的基础上联合使用普罗布考。两组治疗前后两组患者颈内动脉斑块面积、斑块数量、内中膜厚度及血清丙二醛(MDA)、C反应蛋白(CRP)水平的变化及血脂情况。结果:与治疗前相比,两组患者治疗后的颈内动脉斑块面积、斑块数量、内中膜厚度及血清MDA、CRP、血清总胆固醇(TC)、血清三酰甘油(TG)、血清低密度脂蛋白胆固醇(LDL-C)水平均降低,血清高密度脂蛋白(HDL-C)水平升高(P<0.05);与对照组相比,实验组患者颈内动脉斑块面积、斑块数量、内中膜厚度及血清血清丙二醛(MDA)、C反应蛋白(CRP)、血清总胆固醇(TC)、血清三酰甘油(TG)、血清低密度脂蛋白胆固醇(LDL-C)水平较低(P<0.05);血清高密度脂蛋白(HDL-C)水平较高(P<0.05)。结论:普罗布考联合阿司匹林能够更有效溶解脑梗死患者颈内动脉斑块,这可能与其降低血脂水平、改善炎症情况,减轻氧化损伤有关。Objective： To investigate the clinical effect of probucol combined with aspirin in the treatment of patients with carotid plaque cerebral infarction. Methods： 60 cases of carotid plaque cerebral infarction patients from our hospital were selected and randomly divided into the control group and the experiment group with 30 in each group. The control group was treated by conventional therapy and aspirin, while the experiment group was treated on the base of the control group with probucol. Both groups of patients were treated for 3 months. The changes in internal carotid artery plaque area, number of patches, intima-media thickness and serum malondialdehyde（MDA）, C-reactive protein（CRP） levels and blood lipid were compared before and after treatment. Results： Compared with before treatment, the internal carotid artery plaque area, plaque number, intima-media thickness and serum MDA, CRP, TC, TG, LDL-C levels of both groups were lower（P〈0.05）, the HDL-C level was higher（P〈0.05）. Compared with the control group, the internal carotid artery plaque area, plaque number, intima-media thickness and serum MDA, CRP, TC, TG, LDL-C levels were lower（P 0.05）, the HDL-C level was higher in the experiment group（P〈0.05）. Conclusion： The combination of aspirin and aspirin could more effectively dissolve the plaque of carotid artery in patients with cerebral infarction, reduce the blood lipid level.

关 键 词：普罗布考 阿司匹林 颈动脉斑块 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]