奥氮平与喹硫平治疗老年期精神障碍的对比分析  

Comparative analysis of olanzapine and quetiapine in the treatment of senile mental disorders

作　　者：李颖 徐洪常 

机构地区：[1]大连市第七人民医院,116023

出　　处：《中国实用医药》2017年第4期116-118,共3页China Practical Medicine

摘　　要：目的分析奥氮平与喹硫平治疗老年期精神障碍的临床效果。方法 48例老年期精神障碍患者作为本次研究对象,根据用药不同将患者分为研究组和对照组,每组24例。研究组患者应用奥氮平治疗,对照组患者应用喹硫平治疗,对两组患者的临床疗效与不良反应发生情况进行对比。结果研究组临床总有效率(91.67%)高于对照组(87.50%),但比较差异无统计学意义(P>0.05);研究组患者治疗前阳性和阴性症状量表(PANSS)评分为(76.26±3.78)分,治疗2周后为(51.86±4.10)分,治疗6周后为(38.24±3.11)分,对照组患者治疗前PANSS评分为(77.49±4.68)分,治疗2周后为(48.89±3.97)分,治疗6周后为(36.32±3.25)分,治疗后PANSS评分较治疗前明显降低,且研究组患者治疗后的PANSS评分明显低于对照组,差异具有统计学意义(P<0.05)。研究组不良反应发生情况少于对照组,但差异无统计学意义(P>0.05)。结论奥氮平与喹硫平治疗老年期精神障碍均有显著疗效,用药剂量均为较低水平,患者选用两种药物治疗时可根据患者实际情况选用。Objective To analyze clinical effects by olanzapine and quetiapine in the treatment of senile mental disorders. Methods A total of 48 senile mental disorders patients as study subjects were divided by different medication measures into research group and control group, with 24 cases in each group. The research group received olanzapine for treatment, and the control group received quetiapine for treatment. Comparison was made on clinical curative effects and adverse reactions between the two groups. Results The research group had higher total clinical effective rate （91.67%） than the control group （87.50%）, while their difference had no statistical significance （P〉0.05）. The research group had positive and negative syndrome scale （PANSS） scores as （76.26± 3.78） points before treatment, （51.86 ±4.10） points in 2 weeks after treatment and （38.24 ± 3.11） points in 6 weeks after treatment. The control group had PANSS scores as （77.49 ± 4.68） points before treatment, （48.89 ± 3.97） points in 2 weeks after treatment and （36.32 ± 3.25） points in 6 weeks after treatment. Both groups had lower PANSS scores after treatment than those before treatment, and the research group had much lower PANSS scores after treatment than the control group, and their difference had statistical significance （P〈0.05）. The research group had less cases with adverse reactions than the control group, while their difference had no statistical significance （P〉0.05）. Conclusion Olanzapine and quetiapine can both provide excellent curative effect in treating senile mental disorders, along with low medication dosage. Selection of drugs can be made in accordance with practical condition of patients.

关 键 词：奥氮平 喹硫平 老年期精神障碍 

分 类 号：R749[医药卫生—神经病学与精神病学]