脑卒中患者血清可溶性CD14、同型半胱氨酸和7项血脂结果分析  

Analysis of serum soluble CD14, homocysteine and 7 blood lipids in patients with stroke

作　　者：张韶斌[1] 陈斯亮[1] 罗莞超[1] 韦庆文[1] 罗丹[1] ZHANG Shaobin CHEN Siliang LUO Guanchao WEI Qingwen LUO Dan(Department of Clinical laboratory, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China, 518116)

机构地区：[1]深圳市龙岗中心医院检验科,广东深圳518116

出　　处：《分子诊断与治疗杂志》2017年第2期100-103,共4页Journal of Molecular Diagnostics and Therapy

基　　金：深圳市卫计委科研课题(201303209)

摘　　要：目的探讨血清中可溶性CD14(s CD14)、同型半胱氨酸(HCY)和7项血脂指标与脑卒中的相关性。方法采用ELISA法检测195例脑卒中患者及120例健康对照组血清s CD14;使用罗氏C7O2全自动生化分析仪检测195例脑卒中患者及120例健康对照组血清HCY和7项血脂,并对检测结果进行分析。结果脑卒中患者中s CD14、HCY、TG、CHOL、HDL、LDL-C、Apo A、Apo B、LP(a)含量分别为(79.98±36.67)μg/m L、(20.78±17.98)μmol/L、(1.48±0.78)mmol/L、(5.19±0.93)mmol/L、(1.15±0.31)mmol/L、(2.62±0.83)mmol/L、(1.34±0.26)g/L、(0.97±0.76)g/L、(188.07±167.68)mg/L;脑卒中患者血清s CD14、HCY、TG、CHOL、LDL-C含量明显升高,与健康对照组比较,差异具有统计学意义(P<0.05),而脑卒中患者HDL、Apo A、Apo B、LP(a)含量与健康对照组比较,差异无统计学意义(P>0.05)。结论脑卒中患者血清s CD14、HCY和TG、CHOL、LDL-C明显相关,对了解患者的发病和辅助诊断具有重要的临床意义。Objective To investigate the correlation between serum soluble CD14（s CD14）,homocysteine（HCY）, blood lipids and cerebral stroke. Methods ELISA was used to detect the serum levels of s CD14 in 195 patients with stroke and 120 healthy controls. The Roche C7O2 automatic biochemical analyzer was used to detect the serum levels of HCY and serum lipids in 195 patients with stroke and 120 healthy controls, and the test results were analyzed. Results The expression levels of s CD14, HCY, TG,CHOL, HDL, LDL-C, Apo A, Apo B, and LP（a） in the serum of stroke patients were（79.98±36.67） μg/m L,（20.78±17.98） μmol/L,（1.48±0.78） mmol/L,（5.19±0.93） mmol/L,（1.15±0.31） mmol/L,（2.62±0.83） mmol/L,（1.34±0.26） g/L,（0.97±0.76） g/L, and（188.07±167.68） mg/L, respectively. The expression levels of serum s CD14, HCY, TG, CHOL and LDL-C in the stroke patients were significantly increased compared with the levels in the healthy control group（P〈0.05）. There were no significant differences in the levels of HDL, Apo A, Apo B, and LP（a） between the healthy control group and the stroke patients（P〉0.05）. Conclusion The serum levels of s CD14, HCY, TG, CHOL and LDL-C were significantly related to stroke patients, providing important clinical information in understanding the pathogenesis and diagnosis of these patients.

关 键 词：可溶性CD14 同型半胱氨酸 脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.1[医药卫生—临床医学]