3.0T增强MR研究兔眼虹膜周边切除术后对比剂在前后房的分布  

The study on the distribution of contrast agents in the anterior and posterior chamber in the rabbits after the peripheral iridectomy via 3.0 T enhanced MR

作　　者：陈辉[1] 曹丰[1] 毛晓春[2] 

机构地区：[1]湖北省襄阳市中心医院湖北文理学院附属医院放射科,湖北襄阳441003 [2]湖北省襄阳市中心医院湖北文理学院附属医院眼科,湖北襄阳441003

出　　处：《医学影像学杂志》2017年第3期541-544,共4页Journal of Medical Imaging

摘　　要：目的使用3.0T增强MR研究兔眼虹膜周边切除术后前后房房水信号改变。方法 16只健康洁净新西兰白兔单眼接受虹膜周切术,对侧眼为对照眼,兔耳缘静脉注射0.5mol/L钆喷酸葡胺(Gd-DTPA)0.2ml/kg后,MRI连续扫描,分别测量前房、睫状体和后房的平均信号强度,绘制时间-信号增强率曲线,观察对比剂的渗透性及眼内分布。结果双眼睫状体在静脉注射对比剂后信号迅速增强,15min后睫状体的平均信号增强率为1.09±0.058,信号增强达到最高峰,此后信号强度逐渐下降;实验过程中前房的信号缓慢增加,约50~60min到达峰值,信号增强率为0.69±0.063;手术眼后房信号增高,信号增强率为0.62±0.041,对照眼后房未见信号增强,始终为低信号。手术眼后房信号高于对照眼(P<0.05)。结论眼前、后房之间存在房水屏障,3.0T增强MR可用于检测兔眼虹膜周边切除术后对比剂在前后房的分布。Objective To study the signal change of the anterior and posterior chamber in the rabbits after the peripheral iri- dectomy via 3.0 T enhanced MR. Methods Sixteen healthy clean-grade new zealand white rabbits received monocular peripheral iridectomy with the contralateral eyes being taken as control eyes. Gadolinium-diethylenetriamine pentaacetic acids （Gd-DTPA） enhanced MRI were performed with a continuous scanning protocol after injection of Gd-DTPA at a dose of 0.2 ml/kg （0.5 mol/ L） through the ear vein. The signal intensities of anterior chamber, ciliary body and the posterior chamber were measured and the SER-to-time curves （signal enhancement ratio, SER） were drawn to observe the permeability and distribution of the tracer in eyes. Results The signal of ciliary body in bilateral eyes increased immediately and sharply after tracer injection, reached the peak at 15 mins and then decreased gradually over time, with the peak SER being of about 1.09± 0.058. The signal of anterior chamber increased slowly and reached the peak at 50 ~ 60 mins, with the maximum SER being of about 0.69 ~ 0. 063. An in- crease of signal intensity in posterior chamber could be the experimental eyes but could not be in the control ones throughout the study. The SER in posterior chamber of the experimental eye was 0.62 ± 0.041, which was significantly higher than that of the control eyes （ P 〈 0.05）. Conclusion There is a barrier between the anterior and posterior chamber. 3.0 T enhanced MR is a- ble to detect the redistribution of contrast agents in the anterior and posterior chamber in the rabbits after the peripheral iridectomy.

关 键 词：磁共振成像 血-房水屏障 兔 虹膜周边切除术 

分 类 号：R772[医药卫生—眼科] R445.2[医药卫生—临床医学]