肺癌合并静脉血栓栓塞症患者危险因素及预后分析  

Risk Factors for Lung Cancer Patients Combined Venous Thromboembolism and Prognosis

作　　者：陈芙蓉[1] 朱丹[1] 陈慧[1] 袁菲[1] 王临英[1] 黄郑铭 

机构地区：[1]金华市中心医院呼吸内科,321000

出　　处：《医学研究杂志》2017年第3期131-133,7,共4页Journal of Medical Research

摘　　要：目的探讨肺癌患者并发静脉血栓栓塞(VTE)的危险因素,观察肺癌合并VTE患者的预后。方法以2010~2015年笔者医院就诊肺癌合并VTE的患者为研究对象,采用回顾性病例对照研究进行分析。采用单因素分析筛选肺癌患者合并VTE的可能危险因素,再经过非条件Logistic回归分析,寻找肺癌患者合并VTE的危险因素。采用Log-rank方法比较两组患者的生存率差异。结果研究共纳入肺癌合并VTE的患者39例(观察组)及不伴有VTE的肺癌患者82例(对照组)。回归分析结果显示,接受化疗、病理类型为腺癌、肺癌Ⅲ~Ⅳ期及D-二聚体水平升高的肺癌患者合并VTE的OR值分别为2.68、2.10、2.24及2.09,差异均有统计学意义(P<0.05);合并VTE患者的生存率明显低于未合并VTE的肺癌患者,差异具有统计学意义(P<0.05)。结论肺癌的病理类型、肿瘤分期、合并化疗及D-二聚体水平是肺癌患者合并VTE的危险因素,肺癌合并VTE患者的生存时间显著低于未合并VTE的肺癌患者。Objective To investigate the risk factors of venous thromboembolism （VTE） in patients with lung cancer and to observe the prognosis of lung cancer patients with VTE. Methods We studied on patients with lung cancer complicated with VTE from 2010 to 2015 in our hospital. Retrospective case control study was used in the analysis. Single factor analysis was used to screen the possible risk factors of lung cancer patients with VTE. After non conditional Logistic regression analysis, the risk factors of lung cancer patients with VTE were analyzed. The survival rates of the two groups were compared with the Log - rank method. Results A total of 39 patients with VTE of lung cancer （observation group） and 82 patients with lung cancer without VTE （control group） were enrolled in the study. Regression analysis showed that the OR values in VTE with lung cancer patients receiving chemotherapy, pathological type being adenocarcinoma, lung cancer Ⅲ-Ⅳ and increased D - dimer level were 2.68, 2.10, 2.24 and 2.09. All the differences were statistically significant （P 〈 0.05）. The survival rate of the patients with VTE was significantly lower than that of the patients without VTE, and the difference was statistically significant （P 〈 0.05）. Conclusion Pathological types,tumor stage, combined chemotherapy and D - dimer levels were the risk factors of lung cancer patients with VTE. The survival time of lung cancer patients with VTE was significantly lower than that of the patients without VTE.

关 键 词：肺癌 栓塞 危险因素 预后 

分 类 号：R734.2[医药卫生—肿瘤]