改性海藻酸钠聚合物微球制备及药物释放研究  

Preparation and drug release of modified alginate polymer microspheres

作　　者：白雪[1] 周亚敏[1] 吴鲁艳 何飞[1] 石刚[1] 倪才华[1] 

机构地区：[1]江南大学食品胶体与生物技术教育部重点实验室化学与材料工程学院,无锡214122

出　　处：《化工新型材料》2017年第3期256-258,共3页New Chemical Materials

基　　金：国家自然科学基金(21401079);江苏省科技支撑计划-工业部分(BE2012017)

摘　　要：为了制备功能化的栓塞微球,提高微球的载药率,以海藻酸钠(SA)为起始原料,经牛磺酸(TA)改性,采用反相乳液聚合方法将改性后的产物制得栓塞微球。用扫描电子显微镜(SEM)、超景深显微镜、紫外/可见分光光度计等对微球进行了鉴定和表征,并测定了改性前后SA水溶液的黏度。结果表明:改性后的SA溶液在水中的黏度有所降低;微球直径100~500μm;与未改性聚合物相比,改性后的SA微球负载药物阿霉素最高达到30%;载药微球对药物阿霉素的累计释放量增加,缓释现象明显。Embolic microspheres were prepared using alginate as the raw material through a modification by taurine acid,and through inverse emulsion crosslinking method.The polymer microspheres were identified and characterized by scanning electron microscopy（SEM）,super-depth microscope and UV spectrophotometer.The viscosity of the alginate soultion before and after modification was determined.The results showed that the viscosity of modified alginate solution was reduced compared to the original unmodified alginate solution.The diameter of microspheres ranged from 100 to 500μm.Doxorubicin was loaded into the microspheres with loading content of 30%.The drug release study indicated that the release displyed stained profiles.

关 键 词：海藻酸钠 栓塞微球 改性 牛磺酸 缓释 

分 类 号：O631[理学—高分子化学] TQ460.1[理学—化学]