靶向线粒体的载体给药系统研究进展  

Progress of Drug Delivery System Targeting Mitochondria

作　　者：徐鹏程[1] 于鑫 郭兆明[3] 张义木[4] 钮松召[1] 吕晓洁[1] 刘佳[1] 盛华[1] 

机构地区：[1]内蒙古医科大学药学院,呼和浩特010110 [2]费森尤斯卡比(中国)投资有限公司,北京100022 [3]大连理工大学生命与医药学院,辽宁盘锦124221 [4]湖北省麻城市人民医院,湖北麻城438300

出　　处：《内蒙古大学学报（自然科学版）》2017年第2期219-224,共6页Journal of Inner Mongolia University：Natural Science Edition

基　　金：内蒙古自治区自然科学基金(No.2016MS0847);国家自然科学基金(No.81603049);大连理工大学基本科研专项(No.DUT15RC(3)044)资助项目

摘　　要：线粒体是细胞内最重要的细胞器之一,在人体代谢中发挥重要生理作用.线粒体的结构和功能紊乱能导致多种疾病,靶向线粒体给药在现代疾病治疗中具有非常重要的意义.阐述了四类靶向线粒体的载体给药系统,并介绍其局限性和解决思路.Mitochondria are one of the most important organelles in the cells and play a key role in the energy metabolism of human body. Mitochondrial dysfunctions lead to various diseases. Therefore,the development of mitochondria-targeted drug delivery system is very important in the treatment of mitochondria related diseases. In current review, four types of mitochondria-targeted drug delivery were described, as well as their limits and possible solutions.

关 键 词：靶向线粒体 载体给药 纳米载体 

分 类 号：R730.53[医药卫生—肿瘤] R979.1[医药卫生—临床医学]