干扰素调节因子3及其可变剪接体与肿瘤  

Interferon regulatory factor-3 and its alternative splicing isoforms in tumor

作　　者：刘钟桧 孙丹[1] 刘新民[1] 

机构地区：[1]北京大学第一医院老年病内科,100034

出　　处：《国际肿瘤学杂志》2017年第3期196-200,共5页Journal of International Oncology

基　　金：北京市自然科学基金（7151011）

摘　　要：干扰素调节因子3（IRF3）作为干扰素调节因子家族的重要成员，在调控I型干扰素及其下游基因中发挥关键作用，并参与多种生物学过程。研究发现其可抑制肿瘤细胞的生长和转移，并诱导细胞凋亡，发挥抑癌基因作用。该作用机制涉及肿瘤免疫与炎症反应、凋亡及上皮间质转化等过程。IRF3可变剪接体可负性调控IRF3功能，影响肿瘤发生发展。相关的信号通路、发病机制研究为肿瘤早期诊断、治疗提供了新的思路。As a member of interferon regulatory factor family （IRF）, IRF3 plays an important role in triggering the expression of type I interferons and downstream interferon-stimulated genes, contributing to many biological process. Researches have found that it plays an anti-oncogene role in inhibiting tumor proliferation and migration, inducing cell apoptosis. The mechanism involves in tumor immunity and inflammatory reaction, apoptosis and epithelial mesenchymal transition. The alternative splicing isoforms of IRF3 act as negative modulators of IRF3 and affect tumor development progress. The recent signaling pathways and pathogenesis researches provide new ideas for early diagnosis and treatment of cancer.

关 键 词：干扰素调节因子3 剪接体 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]