预防性脑照射的临床共识与进展  

Clinical consensus and progress of prophylactic cranial irradiation

作　　者：柳燕冬 周菊英[1] 

机构地区：[1]苏州大学附属第一医院放疗科,215006

出　　处：《国际肿瘤学杂志》2017年第3期217-220,共4页Journal of International Oncology

摘　　要：预防性脑照射是临床上处理肿瘤脑转移的有效手段，该手段对于微小病灶的杀灭能够有效降低脑转移的发生率，改善患者预后。其有效性在小细胞肺癌中得到了验证，而在非小细胞肺癌（NSCLC）以及乳腺癌中的应用仍然处于探索阶段，对于手术及辅助化疗后ⅢA—N2期NSCLC患者以及曲妥珠单抗治疗的人表皮生长因子受体-2阳性的乳腺癌患者，预防性脑照射有望成为这两类患者的常规治疗手段。Prophylactic cranial irradiation is an effective means of dealing with brain metastasis of cancer, which can reduce the incidence of brain metastasis by killing the micrometastasis and then improve the prognosis. The effectiveness has been verified in small cell lung cancer, but the application is still in the exploration in non-small cell lung cancer （NSCLC） and breast cancer. Prophylactic cranial irradiation is expected to become the conventional treatment for patients with NSCLC of Ⅲ A-N2 stage after operation and adjuvant chemo- therapy or breast cancer of epithelial growth factor receptor-positive after receiving trastuzumab.

关 键 词：颅脑照射 肺肿瘤 乳腺肿瘤 

分 类 号：R730.55[医药卫生—肿瘤]