钛网+膜联合使用修复种植体周围牙槽骨缺损的实验研究  

Guided bone regeneration and simultaneous implant placement using membrane in combination with titanium mesh for repair of alveolar defects in Beagle dogs

作　　者：李慧萍[1] 孙守福 甄锦泽[1] 王烨欣 徐伟峰[1] 郑吉驷[1] 张善勇[1] 朱应超[1] 钟晓琪[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院.口腔医学院口腔外科上海市口腔医学重点实验室,上海200011

出　　处：《中国口腔颌面外科杂志》2017年第2期127-130,共4页China Journal of Oral and Maxillofacial Surgery

基　　金：上海市科学技术委员会西医引导类项目(134119a5400);浦东新区联合攻关项目(PW2016D-1);上海交通大学医学院研究生处课程建设项目;上海交通大学医学院大学生创新训练项目(2016508)

摘　　要：目的 :探讨联合使用钛网+Bio-Gide膜修复比格犬种植体周围牙槽骨缺损的效果。方法 :选择3只成年比格犬,拔除双侧下颌P1-M1,牙槽窝愈合6个月。将3只比格犬(共6侧)随机分为3组,A组使用种植体+骨粉+钛网,B组使用种植体+骨粉+Bio-Gide膜,C组使用种植体+骨粉+钛网+Bio-Gide膜。每侧选取3个位点制备种植窝,在颊侧制作4 mm×4 mm×4 mm牙槽骨缺损,植入种植体并分别覆盖钛网或Bio-Gide膜。于术后6个月处死动物并取材,Micro-CT扫描并三维重建。使用SPSS17.0软件包对测量结果进行统计学分析。结果 :Micro-CT扫描及三维重建结果显示,C组的骨小梁数目、骨小梁厚度、骨密度等数据显著高于另外两组(P<0.01),骨小梁分散度显著低于另外两组(P<0.01)。结论 :联合使用钛网+Bio-Gide膜,对比格犬种植体周围牙槽骨缺损的修复作用显著优于单纯使用钛网或Bio-Gide膜。PURPOSE ： To evaluate the effect of using guided bone regeneration （GBR） with （titanium） Ti mesh and Bio-Gide membrane in repair of alveolar bone defects in Beagle dogs. METHODS ： Three mandibular premolars and one molar on both sides of the jaw in 3 dogs were extracted. Six months after extraction, three implants were inserted into each side, and alveolar bone defects （4 mm×4 mm×4 mm in size） were produced. 24 implants in total 6 sides were assigned to 3 groups and covered with different membranes as follows, group A： implant＋Bio-Oss＋Ti-mesh; group B： implant＋Bio-Oss＋Bio-Gide, group C： implant＋Bio-Oss＋Ti-mesh＋Bio-Gide. The claps were sutured over the membranes to complete the wound closure. The animals were sacrificed after 6 months, and non-decalcified histological specimens of the implants and surrounding tissues were prepared. Micro-CT scanning was carried out to test the results. SPSS17.0 software package was used for statistical analysis. RESULTS ： Micro-CT with three-dimensional reconstruction revealed that bone regeneration in group C was significantly better than the other two groups （P〈0.01）, which indicated faster new bone deposition. CONCLUSION S： Combination of Bio-Gide membrane and Ti-mesh may get a better bone regeneration than Ti-mesh or Bio-Gide used alone.

关 键 词：引导性骨再生术 钛网 牙槽骨缺损 牙种植 比格犬 

分 类 号：R783.6[医药卫生—口腔医学]