PET/CT成像中的呼吸运动衰减校正仿真实验  

Simulation experiment of respiratory motion attenuation correction in PET/CT imaging

作　　者：傅磊[1] 贺建峰[1] 

机构地区：[1]昆明理工大学生物医学工程研究所,云南昆明650500

出　　处：《生物医学工程与临床》2017年第2期107-110,共4页Biomedical Engineering and Clinical Medicine

基　　金：国家自然科学基金资助项目(11265007);教育部回国人员科研启动基金(2010-1561)

摘　　要：目的衰减效应是影响肺部诊断图像的一个重要因素。基于正电子发射计算机断层摄影术/X线计算机体层摄影术(PET/CT),研究衰减校正对于基于PET/CT门控数据呼吸运动的影响。方法使用仿真PET/CT成像的软件GATE(Geant4 Application Tomographic Emission)和像素体模仿真软件NCAT(NURBS cardiac-torso),模拟肺部在PET/CT扫描过程中的运动。然后,利用得到的GATE仿真数据进行门控处理并进行衰减校正。结果经过衰减校正后的门控图像能够进一步有效地减少呼吸运动对PET/CT成像的影响,其图像质量好于未经过衰减校正的门控图像质量,图像的清晰度和准确度得到提高。结论通过利用在GATE仿真平台上进行NCAT像素体模的仿真研究,验证了基于PET/CT门控数据的呼吸运动衰减校正的图像相比于运动模糊的图像和仅仅经过门控校正后的图像,可以进一步提高图像的清晰度和准确度。Objective To study the effect of attenuation correction on the Gating data based on positron emission tomography/X-ray computed tomography（PET/CT）, because of attenuation effect is one of the important factors affecting diagnostic images in lung. Methods The simulation PET/CT software GATE（Geant4 Application Tomographic Emission） and the pixel phantom simulation software NCAT（NURBS cardiac-torso） were used to simulate respiratory movement of lung in PET/CT scanning.Then, the Gating process and attenuation correction with simulation data of GATE were performed. Results The image with Gating process and attenuation correction were further reduced the respiratory movement artifacts in PET/CT image and the quality was better than that of without Gating process and attenuation correction, which were improved the image quality and validity of diagnosis. Conclusion It is demonstrated that NCAT pixel phantom simulation on simulation platform of GATE verifies the image with Gating process and attenuation correction, which can further improve image clarity and accuracy.

关 键 词：正电子发射计算机断层摄影术(PET) 体层摄影术 X线计算机(CT) 门控 呼吸运动 衰减校正 

分 类 号：R817[医药卫生—影像医学与核医学]