p-eIF4E、p-4EBP1和p-Mnk1蛋白表达在进展期鼻咽癌中的作用  

Study the Clinical Significance of Expression of p-eIF4E,p-4EBP-1 and p-Mnk1 Protein in Advanced Nasopharyngeal Carcinoma

作　　者：郑军[1,2] 张春燕[3] 马莉丽[4] 范松青[2] 

机构地区：[1]长治医学院生物化学教研室,046000 [2]湖南省中南大学湘雅二医院病理科 [3]长治医学院附属和平医院妇科 [4]长治医学院病理学教研室

出　　处：《长治医学院学报》2017年第1期9-12,共4页Journal of Changzhi Medical College

基　　金：长治医学院科技创新项目资助(CX201502)

摘　　要：目的:探讨p-eIF4E、p-4EBP1和p-Mnk1蛋白在进展鼻咽癌中的作用。方法:免疫组化SP法检测p-eIF4E、p-4EBP1和p-Mnk1蛋白在鼻咽癌组织中的表达。结果:p-eIF4E和p-4EBP1蛋白在鼻咽转移癌和复发癌中的阳性表达分别高于对应的原发癌(P=0.049,P=0.004;P=0.021,P=0.01);pMnk1蛋白在鼻咽原发癌和对应的转移癌、复发癌中的表达无统计学差异。结论:p-eIF4E和p-4EBP1蛋白过表达可能与鼻咽癌的发生发展及不良预后密切相关,因此,p-eIF4E和p-4EBP1蛋白有望作为鼻咽癌判断预后的较好分子标志物。Objective： To investigate the role of expression of p-eIF4E and p-4EBP-1 and p-Mnkl proteins in advanced Nasopharyngeal Carcinoma. Methods：The expression of p-eIF4E, p-4EBP 1 and p-Mnkl proteins were detected in tissue array by immu- nohistochemistry SP method. Results： The positive expression of p-eIF4E and p-4EBP-1 proteins were signifieamly higher in the recurrent and metastatic tissue than corresponding primary tissue in Nasopharyngeal Carcinoma（P=0. 049, P= 0. 004;P= 0. 021,P=0.01,respectivdy）, but the positive expression of p-Mnk1 protein was no significance in recurrent and metastatic tissue and corresponding primary tissue respectivdy. Conclusion：The over-expression of p-eIF4E and p-4EBP-1 proteins may he closely related to the occurrence and development and adverse prognosis of NPC. Hence, p-eIF4E and p-4EBP1 proteins are expected to be better molecular markers for clinical diagnosis and prognosis of NINE.

关 键 词：p-eIF4E p-4EBP1 p-Mnk1 鼻咽癌 

分 类 号：R739.63[医药卫生—肿瘤]