软组织血管纤维瘤临床病理观察  

Angiofibroma of soft tissue: clinicopathologic features and literature review

作　　者：张玮[1] 李海[2] 宋国新[2] 范钦和[2] 张智弘[2] 娄鉴娟[3] 朱岩[2] ZHANG Wei LI Hai SONG Guo-xin FAN Qin-he ZHANG Zhi-hong LOU Jian-juan ZHU Yan(Department of Pathology, Affiliated Hospital of Stomatology Department of Pathology, the First Affiliated Hospital Department of Radiology, the First Affiliated Hospital Nanjing Medical University, Nanjing 210029, China)

机构地区：[1]南京医科大学附属口腔医院病理科,南京210029 [2]南京医科大学第一附属医院病理科,南京210029 [3]南京医科大学影像科,南京210029

出　　处：《诊断病理学杂志》2017年第3期186-189,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨软组织血管纤维瘤(AFST)的临床病理学特征及鉴别诊断要点。方法对1例AFST进行组织形态学及免疫组化分析,并复习相关文献。结果患者为31岁女性。B超发现右大腿肌层内直径5.5 cm囊性、界清肿块。组织学为散在分布温和的圆形、卵圆形纤维母细胞样肿瘤细胞,背景为明显分支纤细血管网,间质不同程度胶原化及黏液变性;肿瘤细胞vimentin、EMA、ER、CD68和CD163(+),S-100、GFAP、NF、catenin-β、SMA、CD34、ERG和LCA均(-),Ki-67阳性指数3%。术后随访12个月,无复发及转移。结论 AFST是新近报道的少见的良性软组织纤维血管性肿瘤,根据组织病理学及免疫组化特征可确诊。临床工作中注意不要误诊为低度恶性软组织肉瘤。Purpose To investigate the clinicopathological characteristics and differential diagnosis of AFST. Methods One case of AFST was analyzed by light microscopy and immunohistochemical staining,the related literature were reviewed. Results The patient was 31-year-old female. Ultrasonography revealed a 5. 5cm well-circumscribed mass in muscle with cystic change. Microscopically,the bland short-spindle or ovoid tumor cells were distributed haphazardly with abundantly branching small vessels. The stroma were variably collagenous to myxoid. Immunohistochemical stainings with Vim,EMA,ER,CD68,CD163 were positive,whereas S100,GFAP,NF,Catenin-β,SMA,CD34,ERG,LCA confirmed the absence of reactivity. Ki67 was only scattered positive nuclei（ 〈3%）. There were no recurrence and metastasis after 12 month＇s follow-up. Conclusions AFST is a rare and benign fibrovascular soft tissue tumor; it can be distinguished from low-grade sarcoma by evaluation of histopathologic characteristics and the assistance of immunohistochemistry.

关 键 词：软组织血管纤维瘤 免疫组化 临床病理 

分 类 号：R736.4[医药卫生—肿瘤]