妊娠期乳腺假血管瘤样间质增生临床病理观察  

Breast pseudoangiomatous stromal hyperplasia during pregnancy: a clinical pathological analysis

作　　者：陈奕至[1] 穆颖[2] 刘梅[3] 昌红[1] 沈兵[1] 周全[1] CHEN Yi-zhi MU Ying LIU Mei CHANG Hong SHEN Bing ZHOU Quan(Department of Pathology Department of Breast Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China 5. Department of Pathology, the General Hospital of the People＇s Liberation Army, Beijing 100085, Chin)

机构地区：[1]首都医科大学附属北京世纪坛医院病理科,北京100038 [2]首都医科大学附属北京世纪坛医院乳腺科,北京100038 [3]解放军总医院病理科,北京100085

出　　处：《诊断病理学杂志》2017年第3期206-209,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨妊娠期乳腺假血管瘤样间质增生(PASH)的临床病理特征、诊断、治疗与预后。方法复习1例妊娠期乳腺假血管瘤样间质增生的临床病理资料并文献复习。结果患者女性,17岁。妊娠时肿物迅速增大,流产后肿物明显缩小,短期内再次妊娠时,肿物持续增大。粗针穿刺活检结果提示良性间叶源性肿瘤。妊娠4个月时,患者接受肿物切除术。术后病理示乳腺间质内出现特征性的裂隙样中空间隙,形似不规则的血管腔,内衬无明显异型的不连续的梭形细胞。随访36个月,无复发。结论妊娠期以快速增大的包块为特征的乳腺假血管瘤样间质增生非常罕见,确诊依赖于组织病理学检查及免疫组化结果,治疗以手术切除为主,预后好。Objective To investigate the clinical and pathological features of breast pseudoangiomatous stromal hyperplasia（ PASH） during pregnancy and its diagnosis,treatment and prognosis. Method We retrospectively studied the clinical and pathological data of a case of PASH during pregnancy with literature review. Results PASH forming single solid tumors was very rare cases. The patient in our case was a 17 years old female. The breast tumor enlarged rapidly during pregnancy,and significantly reduced after abortion. The tumor size continuously increased again during another pregnancy in a short time. Sarcoma could not be ruled out clinically. The result of the core biopsy suggested a benign mesenchymal tumor. The patient underwent a tumor resection when she was 4 months ＇ pregnant. Pathological examination showed the characteristic crack-like hollow space in the breast stroma,shaping of irregular vessel lumens,and lined with discontinuous spindle cells without cellular atypia. There was no recurrence in a 36 months＇ follow-up.Conclusion Cases of PASH characterized as rapid increasing breast mass during pregnancy are very rare. Diagnosis of the disease depends on histopathologic examination and immunohistochemical results. Surgical resection of the tumor is a major treatment. The prognosis is favorable.

关 键 词：乳腺 妊娠期 假血管瘤样间质增生 

分 类 号：R737.9[医药卫生—肿瘤]