TTF-1和galectin-3在鞍区病变中的表达  

Expression of TTF-1 and galectin-3 in the diseases of sellar region

作　　者：霍真[1] 周良锐 罗玉凤[1] 梁智勇[1] HUO Zhen ZHOU Liang-rui LUO Yu-feng LIANG Zhi-yong(Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100730, China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院病理科,北京100730

出　　处：《诊断病理学杂志》2017年第3期210-214,共5页Chinese Journal of Diagnostic Pathology

基　　金：中国医学科学院研究中心(病理)基金支持项目(编号2015PT320009)

摘　　要：目的探讨TTF-1和galectin-3在鞍区病变中的表达情况。方法选取鞍区病变48例(包括垂体细胞瘤、梭形细胞嗜酸细胞瘤、颗粒细胞瘤、脑膜瘤、毛细胞星形细胞瘤、神经鞘瘤、颅咽管瘤、生殖细胞瘤、垂体腺瘤和Rathke囊肿),另选垂体前叶和垂体后叶组织各10例,采用免疫组化En Vision法检测TTF-1和galectin-3在上述病例中的表达。结果 TTF-1在垂体细胞瘤(6/6)、梭形细胞嗜酸细胞瘤(2/2)、颗粒细胞瘤(2/2)及垂体后叶组织(10/10)中全部(+),在脑膜瘤(0/6)、毛细胞星形细胞瘤(0/4)、神经鞘瘤(0/2)、垂体腺瘤(0/10)、生殖细胞瘤(0/6)、Rathke囊肿(0/5)和垂体前叶组织(0/10)中全部(-),在部分颅咽管瘤(2/5)中灶性(+)。除生殖细胞瘤和部分垂体腺瘤中galectin-3(-)外,其他病例中均(+)。结论 TTF-1仅在垂体细胞瘤、梭形细胞嗜酸细胞瘤、颗粒细胞瘤和垂体后叶组织中阳性,提示这些肿瘤可能为垂体后叶来源,可以通过TTF-1将垂体后叶来源的病变与其他鞍区病变进行鉴别;galectin-3在鞍区多种病变中均阳性,鉴别诊断价值不大。Objective To explore the immunohistochemical expression of TTF-1 and galectin-3 in the diseases of sellar region. Methods TTF-1 and galectin-3 expression was studied in 48 case of surgically resected primary diseases of sellar region by immunohistochemistry,including pituicytomas,spindle cell oncocytomas,glanular cell tumours,pilocytic astrocytomas,menigiomas, pituitary adenomas and schwannomas. Adenohypophyses and neurohypophyses were also investigated. Results TTF-1 was positive in pituicytomas（ 6 /6）,spindle cell oncocytomas（ 2 /2）,glanular cell tumours（ 2 /2）,and neurohypophyses（ 10 /10）,but completely negative in pilocytic astrocytomas（ 0 /4）,menigiomas（ 0 /6）,schwannomas（ 0 /2）,pituitary adenomas（ 0 /10）,germinomas（ 0 /6）,Rathke＇s cleft cyst（ 0 /5）,and adenohypophyses（ 0 /10）. TTF-1 was focal positive in craniopharyngiomas（ 2 /5）. galectin-3 was positive in all cases except germinomas and some pituitary adenomas. Conclusion TTF-1 is only positive in pituicytomas,spindle cell oncocytomas,glanular cell tumoursa and neurohypophyses,indicating the origin of neurohypophyse,and it can helpful for making differential diagnosis from other sellar region diseases. Galectin-3 is of little use in the differential diagnosis of sellar region diseases because of expression ubiquitious.

关 键 词：鞍区 TTF-1 GALECTIN-3 免疫组化 

分 类 号：R739.8[医药卫生—肿瘤]