鸡冠花止血有效部位化学成分研究  

Chemical constituents of effective part in Celosia cristata for treatment of hemostatic

作　　者：冯程[1] 石朗[2] 陈大忠[1] 张洪财[1] 赵润琴[2] FENG Cheng SHI Lang CHEN Da-zhong ZHANG Hong-cai ZHAO Run-qin(Research Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China Department of Pharmacy, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中草药》2017年第4期653-656,共4页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省自然科学基金项目(H201468)

摘　　要：目的研究鸡冠花Celosia cristata止血有效部位的化学成分。方法采用正相硅胶柱色谱、ODS柱色谱和HPLC等方法对其化学成分进行分离、纯化,根据理化性质及波谱数据鉴定化合物结构。结果从鸡冠花95%乙醇提取物的醋酸乙酯萃取部位分离得到9个化合物,分别鉴定为northalifoline(1)、韭子碱乙(2)、异鼠李素-3-O-β-D-葡萄糖苷(3)、1-feruloyl-β-D-glucopyranoside(4)、阿魏酸酯6-O-β-D-吡喃葡萄糖酯[5(α构型)、6(β构型)]、2-甲氧基-4-(2-丙烯基)-苯基-β-D-吡喃葡糖苷(7)、羽扇豆醇(8)、阿魏酸(9)。结论所有化合物均为首次从鸡冠花植物中分离得到,也均为首次从青葙属植物中分离得到。Objective To study the chemical constituents of effective fraction in Celosia cristata for hemostatic. Methods The chemical constituents were isolated and purified by chromatography on silica gel, ODS, and preparative HPLC methods. Their structures were determined by physicochemical properties and spectral data. Results Nine compounds have been found in the ethyl acetate fraction of 95% ethanol extraction from C. cristata which were obtained and identified as northalifoline （1）, 1,2,3,4-tetrahydro-4-hydroxy-4-quinolin carboxylic acid （2）, isorhamnetin-3-O-β-D-glucoside （3）, 1-feruloyl-β-D-glucopyranoside （4）, Feruloyl 6-O-β-D-glucopyranose ester[5 （α structure）, 6 （β structure）], 2-methoxy-4-（2-propenyl） phenyl β-D-glucopyranoside （7）, lupeol （8）, and ferulic acid （9）. Conclusion All compounds are not only isolated from C. cristata for the first time but also from the plants of genus Celosia L. for the first time.

关 键 词：鸡冠花 止血有效部位 阿魏酸 韭子碱乙 northalifoline 

分 类 号：R284.1[医药卫生—中药学]