偏头痛患者的跨时决策研究  

Changes of intertemporal choice in migraine sufferers

作　　者：吴兴启 代迎菊 马慧娟[1] 柏同健 高建国[1] 汪凯[1] Wu Xingqi Dai Yingju Ma Huijuan Bai Tongjian Gao Jianguo Wang Kai(Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Chin)

机构地区：[1]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《中华行为医学与脑科学杂志》2017年第3期226-231,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81300944,91232717）

摘　　要：目的探讨偏头痛患者的跨时决策是否受损。方法采用跨时决策（Intertemporalchoice）范式，对30名偏头痛患者及30名健康对照进行跨时决策的研究。结果（1）偏头痛组选择延迟的较大奖赏选项的比例显著低于健康对照组，分别为（18．15±17．53）％和（35．37±20．70）％，差异有统计学意义（t=3．31，P〈0．05）。在now选择条件下和not—now选择条件下偏头痛组[（18．33±21．00）％，（17．96±18．09）％]选择延迟的较大奖赏（long large reward，LL）选项的比例均低于健康对照组[（35．56±21．52）％，（35．19±22．05）％]，差异有统计学意义（t=3．31，P〈0．05；声3．14，P〈0．05）。（2）Pearson相关分析显示色字干扰试验结果与now条件下LL选择比例（r=0．49，P=0．006）及总的LL选择比例（r=0．42，P=0．021）显著正相关。结论偏头痛患者跨时决策能力明显受损，跨时决策与执行功能相关。Objective To investigate whether there are changes in the ability of intertemporal choices in migraine sufferers. Method Thirty migraine sufferers and thirty healthy controls were investigated by Delay-discount Test. Results （ 1 ） The ratio of later-large （LL） choice in migraine suffers （ （ 18.15 ± 17.53） % ） was significantly lower than that in the healthy controls （（ 35.37± 20.70）% ） , and the difference was statistically significant（t= 3.31, P〈0.05 ）.Under the immediate option for now selection conditions and no immediate option for not-now selection conditions, the ratio of later-large （LL） choice in migraine suffers （（18.33±21.00）% , （17.96± 18.09）%） was also significantly lower than that in the healthy controls （ （35.56±21.52） %, （ 35.19±22.05 ） % ）, and the difference was statistically significant（t= 3.31, P〈0.05 ; t= 3.14, P〈0.05）. （2） Pearson correlation analysis showed that the Stroop Test of migraineurs was positively correlated with LL selection ratio under now conditions （r= 0.49, P= 0.006） and total LL selection （r= 0.42, P= 0.021 ） . Conclusion The ability of intertemporal choices in migraine sufferers has been impaired, which is correlated with executive function.

关 键 词：偏头痛 跨时决策 自我控制 决策 

分 类 号：R747.2[医药卫生—神经病学与精神病学]