Y染色体短串联重复序列基因座基因频率在主动与冲动攻击行为群体中分布的比较  

Comparison of gene frequencies of short tandem repeats loci on Y Chromosome between offenders with initiative-aggressive behavior and impulsive-aggressive behavior

作　　者：张书友[1] 巴华杰[2] 杨春[1] 王寅[1] 赵汉清[1] 高志勤[1] Zhang Shuyou Ba Huajie Yang Chun Wang Yin Zhao Hanqing Gao Zhiqin(Psychiatry Center of Chinese PLA , the PLA 102nd Hospital, Changzhou 213003, China DNA Laboratory, Public Security Bureau of Changzhou, Changzhou 213003, China)

机构地区：[1]解放军第102医院全军精神医学中心,常州213003 [2]常州市公安局刑警支队DNA室,常州213003

出　　处：《中华行为医学与脑科学杂志》2017年第3期237-241,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：南京军区医学科技创新项目（2013MS016）

摘　　要：目的比较22个Y染色体短串联重复序列（STR）基因座等位基因及单倍型频率在主动、冲动攻击行为群体中的分布，推测与主动、冲动攻击行为发生相关的遗传因素。方法运用Power Plex Y23 System荧光标记复合扩增体系对271例主动攻击行为服刑人员与271例冲动攻击行为服刑人员样本分别进行聚合酶链反应（PCR）复合扩增，然后应用AB3500xL型基因分析系统对扩增产物进行电泳和基因检测，比较2组22个Y-STR基因座等位基因及单倍型频率的差异。结果DYS437基因座等位基因频率在主、冲动攻击行为群体分布差异有统计学意义（P=0．022）；单个等位基因频率比较提示2组在DYS437基因座等位基因14的频率（主动攻击行为组：69．37％；冲动攻击行为组：58．67％）分布差异有统计学意义（P=0．009）；其余Y—STR基因座等位基因频率及单倍型频率在两个群体中分布差异均无统计学意义（均P〉0．05）。结论DYS437基因座可能与攻击行为的发生有关；在攻击行为群体中DYS437基因座的等位基因14可能为主动攻击行为的易感因素，冲动攻击行为的抗性因素。Objective To explore the distributional differences of the gene frequencies of 22 short tandem repeats loci on Y Chromosome （Y-STRs） between offenders with Initiative-aggressive behavior and impulsive-aggressive behavior,and to probe into the genetic factors of initiative-aggressive behavior and impulsive-aggressive behavior. Methods Biological samples of 271 offenders with initiative-aggressive behavior and 271 offenders with impulsive-aggressive behavior were collected and PCR compound amplification was carried out with the aid of PowerPlex Y23 System. Then the PCR products were subjected to electrophoresis and gene detection with AB3500xL gene analysis system so as to calculate and compare the alleles and haplotypes of 22 Y-STRs gene frequency in the two groups. Results The distribution of allele frequency were significantly difference in locus DYS437（P= 0.022）between two groups ,not in the other 21 Y-STRs loci（ all P〉 0.05）. Univarite analysis showed significant differences at allelle 14 in locus DYS437 between both groups （ initiative-aggressive behavior group ： 69.37% ; impulsive-aggressive behavior group ： 58.67% ; P = 0.009 ）. Conclusion Loci DYS437 may be associated with aggressive behavior. In the group of aggressive behavior, allelle 14 on locus DYS437 may be the susceptible factor of initiative-aggressive behavior and the resistant factor of impulsive-aggressive.

关 键 词：主动攻击行为 冲动攻击行为 人类Y染色体 短串联重复序列(STR) 遗传多态性 

分 类 号：R749[医药卫生—神经病学与精神病学]