美沙酮维持治疗海洛因依赖患者抑郁焦虑情绪与外周血细胞相关性分析  

A correlation analysis on depression and anxiety and peripheral blood cell counts in heroin-dependent patients receiving methadone maintenance treatment

作　　者：朱军红[1] 钟宝亮[1] 徐丽娟[1] 胡萍[2] Zhu Junhong Zhong Baoliang Xu Lijuan Hu Ping(Affiliated Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430012, China Wuhan Infectiou Disease Medical Center, Wuhan 430040, China)

机构地区：[1]华中科技大学同济医学院附属精神卫生中心,武汉430012 [2]武汉市医疗救治中心,武汉430040

出　　处：《中华行为医学与脑科学杂志》2017年第3期242-246,共5页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的探索美沙酮维持治疗（methadone maintenance treatment，MMT）海洛因依赖患者的部分外周血细胞（白细胞、中性粒细胞、淋巴细胞、红细胞和血红蛋白）指标与其抑郁焦虑症状的关系。方法252例接受了血常规实验室检查的MMT海洛因依赖患者完成一般情况问卷、SAS和SDS的评定，并与109例健康体检者的血常规数据对照。采用多元线性回归分析外周血细胞指标与抑郁焦虑症状的关系。结果MMT患者的白细胞（14．7％）、中性粒细胞（12．7％）和淋巴细胞（9．9％）计数偏高比例均显著高于健康对照（分别为3．7％，2．8％，2．8％，均P〈0．05），红细胞计数（10．3％）和血红蛋白（11．5％）浓度偏低比例均显著高于健康对照（分别为4．6％，4．6％，均P〈0．05）。多元回归模型中，白细胞（β=0．261，P〈0．01）、中性粒细胞（β=0．264，P〈0．01）、淋巴细胞（β=0．196，P=0．003）和红细胞（β=-0．144，P=0．021）计数与抑郁评分独立相关，白细胞（β=0．298，P〈0．01）和中性粒细胞（β=0．269，P〈0．01）计数与焦虑评分存在独立相关。结论改善炎症和营养不良状态可能有助于减少MMT患者的抑郁焦虑情绪。Objective To explore the relationship between depression and anxiety and peripheral blood cell counts （ white blood cell （WBC） , neutrophil （NEU） , lymphocyte （ LYM ）, red blood cell （RBC） and hemoglobin （HGB）） of heroin-dependent patients receiving methadone maintenance treatment （MMT）. Methods Two hundred and fifty-two MMT heroin addicts, who had received peripheral blood tests within the week prior to the study, were administered with a general information questionnaire, SDS and SAS. The results of blood tests of these patients were compared with those of 109 healthy people in physical examination. Multiple linear regression was used to analyze associations between indicators of peripheral blood cell counts and depressive and anxiety symptoms. Results Compared with healthy controls, MMT patients had significantly higher proportions of elevated WBC（ 14.7% vs 3.7%） , NEU（ 12.7% vs 2.8%） and LYM （9.9% vs 2.8% ） counts （ all P〈0.05） , and low RBC （ 10.3% vs 4.6%） counts and HGB （ 11.5% vs 4.6% ） concentration （both P〈 0.05）. Multivariate linear regression analysis showed that blood cell counts of WBC （β= 0.261, P〈0.01） ,NEU （β=0.264, P〈0.01） ,LYM （β=0.196, P= 0.003） and RBC （β=-0.144, P= 0.021） were independently associated with depression;and blood cell counts of WBC （β= 0.298, P〈0.01） and LYM （β= 0.269, P〈0.01） were independently associated with anxiety. Conclusion Improving the in- flammatory and malnutrition status may be helpful for reducing depressive and anxiety symptoms of MMT heroin addicts.

关 键 词：美沙酮维持治疗 海洛因依赖 血细胞计数 抑郁 焦虑 

分 类 号：R749.64[医药卫生—神经病学与精神病学]