109例直肠神经内分泌肿瘤患者的临床病理特征与预后分析  

Clinicopathological Characteristics and Prognosis of Rectal Neuroendocrine Tumors

作　　者：范振列[1] 杨召[1] 乔友林[1] 袁兴华[1] FAN Zhen-lie YANG Zhao QIAO You-lin et al.(National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China)

机构地区：[1]国家癌症中心/中国医学科学院北京协和医学院肿瘤医院,北京100021

出　　处：《中国肿瘤》2017年第4期308-314,共7页China Cancer

基　　金：辉瑞公司胃肠胰腺神经内分泌肿瘤临床流行病学研究专项基金(WS1910269)

摘　　要：[目的]探讨直肠神经内分泌肿瘤的临床病理特征及预后。[方法]回顾性分析109例直肠神经内分泌肿瘤患者的临床病理及随访资料。观察患者肿瘤的分类情况,并通过Kaplan-Meier法估计受试者的预后生存情况,利用Cox等比例风险模型来探讨影响直肠神经内分泌肿瘤预后的危险因素。[结果]109例直肠神经内分泌肿瘤患者,其中神经内分泌肿瘤患者91例(83.48%)、神经内分泌癌患者和未知分级患者各9例(8.26%)。患者的平均年龄(50.58±11.90)岁,男、女性别比为1.51∶1,且多数患者(90.83%)居住在城镇。经过8.12年(中位随访时间,95%CI:7.32~8.85年)的随访,全组患者的3年、5年和10年生存率分别为91.23%(95%CI:83.83%~95.34%)、88.20%(95%CI:80.14%~93.12%)和84.20%(95%CI:74.85%~90.29%)。Cox等比例风险模型的结果显示,年龄(HR=5.80,95%CI:1.36~24.77)、淋巴结转移(HR=7.15,95%CI:2.27~24.83)和远处转移(HR=7.42,95%CI:1.98~27.76)是影响直肠神经内分泌肿瘤预后的独立危险因素。[结论]直肠神经内分泌肿瘤多发生于城镇地区的中年男性人群,预后较好。年龄、淋巴结转移和远处转移是直肠神经内分泌肿瘤预后的独立危险因素。[Purpose] To analyze the clinicopathological characteristics and prognosis of rectal neuroendocrine tumor（RNET）. [Methods] The clinical and pathological characteristics and prognosis of109 patients with RNET were retrospectively analyzed. Kaplan-Meier method was used to calculate the overall 3-,5- and 10- year survival rate and Cox proportional hazard model was applied to analyze the prognostic factors. [Results] A total of 109 patients were included in the final analysis,including91 cases（83.48%） of neuroendocrine tumor（NET）,9 cases（8.26%） of neuroendocrine carcinoma（NEC） and 9 cases（8.26%） of unknown classification. The average age at diagnosis was（50.58 ±11.90） years,male/female ratio was 1.51 and most cases were residents living in the urban area.The median follow-up duration was 8.12（95%CI：7.32~8.85） years;the 3-,5- and 10-year overall survival rates were 91.23%（95% CI：83.83% ~95.34%）,88.20%（95% CI：80.14% ~93.12%） and84.20%（95% CI：74.85% ~90.29%）,respectively. Cox proportional hazard model showed that age（HR=5.80,95%CI：1.36~24.77）,lymph node metastasis（HR=7.15,95%CI：2.27~24.83） and distant metastasis（HR =7.42,95% CI：1.98 ~27.76） were independent prognostic risk factors of RNET.[Conclusion] RENT usually occur in older（≥ 60 years old）,male and urban residents with a good prognosis. Age,lymph node metastasis and distant metastasis are independent prognostic risk factors of RNET.

关 键 词：直肠神经内分泌肿瘤 临床病理特征 预后 

分 类 号：R735.3[医药卫生—肿瘤]