植入用缓释氟尿嘧啶致腹壁下包裹性积液合并慢性腹痛1例  

Abdominal encapsulated effusion with chronic pain induced by misuse of sustained-release fluorouracil implants

作　　者：姚爱华[1] 吕陵[1] 王平[1] 成峰[1] Ai-Hua Yao Ling Lv Ping Wang Feng Cheng(Liver Transplantation Center, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China)

机构地区：[1]南京医科大学第一附属医院肝脏外科,江苏省南京市210029

出　　处：《世界华人消化杂志》2017年第8期760-762,共3页World Chinese Journal of Digestology

基　　金：江苏省六大人才高峰基金资助项目;N o.2015-WSW-038~~

摘　　要：植入用缓释5-氟尿嘧啶(5-fluorouracil,5-Fu)目前广泛用于消化道癌、胰腺癌、肝癌等术后腹腔区域化疗.术中腹腔植入缓释5-Fu应掌握正确的方法.本文报道1例结肠癌根治术中因缓释5-Fu植入不当,局部高浓度的药物刺激腹壁造成局限性化学性腹膜炎,致腹壁下包裹性积液、慢性腹痛的病例,由CT和超声引导下穿刺确诊,置管反复冲洗、引流治愈.Sustained-release 5-fluorouracil（5-Fu） implants have been extensively used in local peritoneal chemotherapy for gastrointestinal tract cancer, pancreatic cancer and hepatic cancer. The drug should be correctly implanted or delivered during surgery. Here we report a 61-year-old woman who suffered severe abdominal pain after radical colectomy for sigmoid colon cancer. CT and ultrasound revealed an encapsulated fluid collection beneath the middle abdominal wall, and the particle in the aspirated fluid demonstrated a sustained-release-5-Fu-implant-associated chemical peritonitis, which was eventually cured by irrigation and drainage.

关 键 词：缓释氟尿嘧啶 区域化疗 腹腔化疗 化学性腹膜炎 并发症 

分 类 号：R735.35[医药卫生—肿瘤]