缺血性脑血管疾病患者高尿酸血症与颅内动脉粥样硬化狭窄程度相关性分析  

Correlation analysis between hyperuricemia and intracranial atherosclerotic stenosis degree of patients with ICVD

作　　者：杨小梅[1] 

机构地区：[1]安康市中心医院,陕西安康725000

出　　处：《临床医学研究与实践》2017年第10期28-29,共2页Clinical Research and Practice

摘　　要：目的探讨缺血性脑血管疾病患者高尿酸血症与颅内动脉粥样硬化狭窄程度的相关性。方法选取2015年1月至2016年1月我院收治的128例缺血性脑血管疾病患者,所有患者入院后均行常规生化及数字减影血管造影(DSA)等辅助检查。观察并记录患者中颅内动脉粥样硬化有无狭窄及狭窄程度例数和生化检查中血尿酸水平,并比较有无狭窄及不同狭窄程度之间的血尿酸水平。结果 128例患者中无狭窄42例(32.8%),狭窄86例(67.2%),且两组在年龄上比较差异有统计学意义(P<0.05)。无狭窄患者血尿酸水平较狭窄患者低,且不同狭窄程度之间血尿酸水平均有明显差异(P<0.05),且随着狭窄程度的不断加重,血尿酸水平逐渐升高(P<0.05)。结论颅内动脉粥样硬化狭窄除年龄、高血压、高血脂、糖尿病等高危因素外,高尿酸血症也可作为颅内动脉粥样硬化狭窄的一项独立高危因素存在,且因其与颅内动脉粥样硬化狭窄及程度有正相关性,可考虑作为临床上颅内动脉粥样硬化狭窄程度的评估标准。Objective To investigate the correlation between hyperuricemia and intracranial atherosclerotic stenosis degree of patients with ischemic cerebral vascular disease （ICVD）. Methods One hundred and twenty-eight patients with ICVD in our hospital from January 2015 to January 2016 were selected and given routine biochemistry and digital subtraction angiography （DSA）. The numbers of cases whether has intracranial atherosclerosis stenosis and the degree of stenosis and the level of biochemical tests of blood uric acid were observed and recorded, and to compare levels of blood uric acid of patients whether has stenosis and the different degrees of stenosis. Results Of 128 cases, 42 cases with no stenosis （32.8%）, 86 cases with stenosis （67.2%）, the difference of ages between the two groups was statistically significant （P〈0.05）. The blood uric acid of patients without stenosis was lower than patients with stenosis, and the blood uric acid levels were significantly different between patients with different levels of stenosis （P〈0.05）; with the increasing of stenosis degree, the level of blood uric acid increased （P〈0.05）. Conclusion Except the age, high blood pressure, hyperlipidemia and diabetes, hyperuricemia can be seen as one independent risk factor for intracranial atherosclerosis stenosis. It has positive correlation with intracranial atherosclerotic stenosis degree, which can be considered as assessment criteria for the degree of intracranial atherosclerosis stenosis on clinic.

关 键 词：缺血性脑血管疾病 高尿酸血症 颅内动脉粥样硬化狭窄程度 

分 类 号：R743.3[医药卫生—神经病学与精神病学]