血浆黏附分子及游离氨基酸与卵巢癌的关系分析  

Analysis on the relationship between plasma adhesion molecules, free amino acids and ovarian cancer

作　　者：蒋珊珊[1] 胡京辉[1] 章杰捷[2] 

机构地区：[1]浙江省人民医院妇科,杭州331004 [2]浙江省肿瘤医院妇瘤科,杭州310022

出　　处：《中国医师杂志》2017年第3期385-387,共3页Journal of Chinese Physician

基　　金：2015浙江省卫计委课题（2015KYB015）

摘　　要：目的分析及研究血浆黏附分子及游离氨基酸与卵巢癌的关系。方法将2015年3月至2016年5月期间在本院进行诊治的67例卵巢癌患者选为观察组，并将同时期的67例健康妇女选为对照组，然后检测与比较两组妇女的血浆黏附分子及游离氨基酸水平，同时比较观察组中不同分期及分化程度卵巢癌患者的检测水平，同时以Logistic分析法分析血浆黏附分子及游离氨基酸与卵巢癌的关系。结果观察组的血浆黏附分子水平均高于对照组（P〈0.05），血浆游离氨基酸水平则低于对照组（P〈0.05）；不同分期及分化程度卵巢癌患者的血浆黏附分子及游离氨基酸水平差异有统计学意义（P〈0.05）；且以Logistic分析法显示，血浆黏附分子及游离氨基酸均与卵巢癌密切相关（P均〈0.05）。结论卵巢癌患者的血浆黏附分子及游离氨基酸均呈现异常表达的状态，且不同分期及分化程度卵巢癌患者的表达水平也存在一定差异，因此上述指标在卵巢癌患者中的检测价值较高。Objective To analyze and study the relationship between plasma adhesion molecules, free amino acids and ovarian cancer. Methods A total of 67 patients with ovarian cancer in our hospital during the time of March 2015 to May 2016 were selected as the observation group ,and 67 healthy women at the same time were selected as the control group. The plasma adhesion molecules and free amino acids levels of two groups were detected and compared, The detection levels of observation group with different stages and degree of differentiation of ovarian cancers were compared. The relationship between plasma adhesion molecules, free amino acids and ovarian cancer were analyzed by the Logistic analysis. Results The plasma adhesion molecules levels of observation group were all higher than those of control group （ P 〈 0.05 ）, the plasma free amino acids levels were all lower than those of control group （P 〈 0.05 ） , and the detection levels of observation group with different stages and degree of differentiation of ovarian cancer plasma adhesion molecules and free amino acid levels had significant differences （ P 〈 0.05 ）. The Logistic analysis showed that the plasma adhesion molecules and free amino acids had close relationship to the ovarian cancer （ all P 〈 0. 05 ）. Conclusions The plasma adhesion molecules and free amino acids of the patients with ovarian cancer show abnormal expression state, and the expression levels of patients with different stages and degree of differentiation of ovarian cancer have certain differences, so the detection value of those indexes in the patients with ovarian cancer is higher.

关 键 词：细胞黏附分子 氨基酸类 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]