大蒜素注射液对Ⅲ型前列腺炎疼痛的临床疗效及其前列腺液p38MAPK、COX-2的影响  

Clinical Efficacy of Garlicin Injection on Ⅲ Prostatitis Pain and Change of Prostatic Fluid p38MAPK and COX-2

作　　者：张建军[1] 王晨宇[1] 唐则天 南玉奎[1] 李鸣[1] 

机构地区：[1]新疆维吾尔自治区人民医院泌尿外科,乌鲁木齐830001

出　　处：《世界中医药》2016年第9期1803-1806,1810,共5页World Chinese Medicine

基　　金：新疆维吾尔自治区卫生厅适宜卫生技术推广项目(编号:WST20110972)

摘　　要：目的:观察大蒜素注射液在治疗Ⅲ型前列腺炎疼痛方面的临床疗效,并借此探讨该注射液对前列腺液p38MAPK、COX-2的影响。方法:选取2015年7月至2016年2月收住我科的Ⅲ型前列腺炎并以疼痛为主要表现的男性患者90例,随机分成对照组和观察组,各45例。对照组服用塞来昔布片,2片/d,1次/片,治疗14 d,观察组采用大蒜素注射液配生理盐水静脉推注,同样治疗14 d后观察2组治疗的临床疗效、各临床功能评分、药物不良反应、前列腺液p38MAPK、COX-2及血浆IL-6、TNF-α水平的变化等情况。结果:1)治疗后观察组有效率86.67%,对照组有效率68.89%,2组有效率比较差异具有统计学意义(P<0.05);2)2组患者治疗前各评分无统计学差异(P>0.05),治疗后,NIH-CPSI、QOL均较治疗前降低,IIEF-5均升高,但均为对照组变化更明显,差异有统计学意义(P<0.05);3)不良反应中,对照组出现10例(33.00%),观察组4例(8.80%),观察组不良反应明显低于对照组(P<0.05);4)2组患者治疗前前列腺液p38MAPK、COX-2及血浆IL-6、TNF-α水平比较差异无统计学意义(P<0.05)。治疗14 d后,上述指标均较治疗前下降,但观察组下降更明显(P<0.05)。结论:大蒜素注射液在治疗Ⅲ型前列腺炎疼痛方面有显著的临床效果,且不良反应较传统止痛药明显降低,值得推广,同时,该药对前列腺炎性反应程度的指标也有明显降低作用,考虑其可能是通过类似机制起作用。Objective： To observe the effect of the Garlicin injection in the treatment of Ⅲ prostatitis pain,and to discuss the change of prostatic fluid p38 MAPK,COX-2. Methods： Total 90 patients with Ⅲ prostatitis pain were admitted to our department from July 2015 to February 2016,and then randomly divided into control group and observation group,with 45 cases in each group. Control group was given Celecoxib tablets,2 / day,1 / piece,for 14 days,the observation group were injected by Garlicin with normal saline bolus,the clinical efficacy of the treatment,all clinical score,adverse drug reactions were observed 14 days after treatment,as well as other changes in p38 MAPK,COX-2,IL-6,TNF-α. Results： 1） The effective rate of the observation group after treatment was 86. 67%,significantly higher than the control group＇s 68. 89%（ P〈0. 05）; 2） Each score in two groups had no significant difference before treatment（ P〉0. 05）,but after treatment,the NIH-CPSI,QOL decreased IIEF-5 increased in both two groups,but the changes were more obvious in the control group,the differences were statistically significant（ P〈0. 05）;3） As for the adverse reactions,the control group had 10 cases（ 33. 00%） but observed 4 cases（ 8. 80%）,which was significantly higher than the observation group（ P〈0. 05）; 4） Before treatment,the differences on prostatic fluid p38 MAPK,COX-2and plasma IL-6,TNF-α level were not statistically significant（ P〉0. 05）. But 14 days after treatment,the index decreased in both two groups,but the observation group decreased more significantly（ P〈0. 05）. Conclusion： The Garlicin injection can achieve significant clinical efficacy,with less adverse reactions than conventional treatment,which is worthy to be promoted in clinical practice. Meanwhile,the drug may work on the level of p38MAPK、COX-2、IL-6、TNF-α by reducing inflammation factors.

关 键 词：大蒜素 前列腺炎痛 前列腺液 P38MAPK COX-2 疗效 

分 类 号：R285.6[医药卫生—中药学]