玻璃体腔内注射抗VEGF药物和常规方法在Coats病患者中的疗效对比观察  

Comparative Observation of the Efficacy of VEGF and Conventional Methods in the Treatment of Coats Patients with Vitreous Cavity Injection

作　　者：林玉华[1] 王清[1] 马盼盼[1] 朴天华[1] 杨晓霞[1] 

机构地区：[1]牡丹江医学院附属红旗医院,牡丹江157000

出　　处：《航空航天医学杂志》2017年第3期259-260,共2页Journal of Aerospace medicine

基　　金：黑龙江省卫生计生委科研课题(2014-190)

摘　　要：目的对比玻璃体腔内注射抗VEGF药物和常规方法对Coats病患者治疗疗效的差异。方法 2012年9月~2016年1月共收治确诊Coats病患者50例,将其作为观察对象。50例患者应用数字随机表方法进行分组处理,对照组、观察组中分别纳入患者25例。对照组患者采用玻璃体腔内注射曲安奈德药物治疗方案,观察组患者采用玻璃体腔内注射抗VEGF药物治疗方案。治疗结束7 d后对患者进行复查,以视力改善情况以及并发症发生率为观察指标,对比两组患者在不同治疗方案下的疗效差异。结果两组患者治疗前视力对比无显著差异(P>0.05);经治疗后,两组患者视力均较治疗前有所提升,且观察组患者视力改善显著高于对照组(P<0.05)。两组患者并发症发生率对比无显著差异(P>0.05)。结论 Coats病患者应用玻璃体腔内注射抗VEGF药物方案进行治疗的效果确切,在改善患者视力方面的效果优于常规曲安奈德治疗方案,且不良反应少,有应用价值。Objective To compare the therapeutic effect of Coats patients treated with anti VEGF drugs and conven- tional methods in the vitreous cavity. Methods 50 cases of Coats＇s disease were admitted in our hospital during the pe- riod of September 2012 - January 2016, and cases were treated as the observation object. 50 cases were treated by digital random table method, and 25 cases were included in the control group and the observation group. Control group patients by intravitreal injection of triameinolone acetonide drug regimens were observed groups of patients by intravitreal injection of anti VEGF drug regimens. After 7d treatment, the patients were reviewed, the visual acuity improvement and the inci- dence of complications were observed, compared with the two groups of patients in different treatment options. Results Two groups of patients with treatment of visual contrast there was no significant difference （ P 〉 0. 05 ）. After the treat- ment, the visual acuity for the patients in the two groups were compared with those before treatment improved, and pa- tients in the observation group improvement in visual acuity was significantly higher than that of the control group （ P 〈 0.05 ）. There was no significant difference in incidence of complications between the two groups （ P 〉 0. 05 ）. Conclu- sions Coats disease patients were treated with intravitreal injection of anti VEGF drug regimens were curative effect ex- act, in improving visual acuity is better than conventional triamcinolone acetonide treatment scheme, and less adverse re- action, has application value.

关 键 词：COATS病 玻璃体 VEGF 临床疗效 

分 类 号：R776.4[医药卫生—眼科]