功能性消化不良与胃幽门螺旋杆菌感染相关性研究  

Correlation between Functional Dyspepsia and Gastric Helicobacter Pylori Infection

作　　者：焦艳 

机构地区：[1]重庆市大足区人民医院,重庆402360

出　　处：《中国医学创新》2017年第9期25-28,共4页Medical Innovation of China

基　　金：重庆市大足区级课题(DZKJ;2014A;CC1021)

摘　　要：目的:探讨幽门螺杆菌(Helicobacter pylori,Hp)感染与不同类型的功能性消化不良(FD)之间的相关性。方法:收集2014年1月-2015年5月在本院内镜中心确诊为功能性消化不良的患者240例,包括餐后不适综合征(PDS)120例、上腹疼痛综合征(EPS)120例。根据胃幽门螺旋杆菌阳性表达情况不同分为三联治疗组、序贯治疗组及对照组,各80例,对比各组患者FD的治疗效果,并探讨幽门螺杆菌感染与FD治疗相关性。结果:上腹疼痛综合征组的Hp阳性检出率高于餐后不适综合征组,差异有统计学意义(P<0.05)。三组两种亚型的功能性消化不良患者治疗后的症状改善均优于治疗前,差异均有统计学意义(P<0.05);序贯治疗组两种亚型的功能性消化不良患者的症状改善均明显优于三联治疗组,三联治疗组的症状改善均优于对照组,差异均有统计学意义(P<0.05)。序贯治疗组两种亚型患者的总有效率均明显优于三联治疗,三联治疗的总有效率均优于对照组,差异均有统计学意义(P<0.05)。序贯治疗组两种亚型的功能性消化不良患者的Hp清除率均明显优于三联治疗组,三联治疗组的Hp清除率均优于对照组,差异均有统计学意义(P<0.05)。结论:不同类型的功能性消化不良与Hp感染具有相关性,序贯疗法对功能性消化不良幽门螺旋杆菌的根除效果更佳。Objective： To investigate the relationship between Helicobacter pylori （ Hp ） infection and different types of functional dyspepsia.Method： A total of 240 patients with functional dyspepsia admitted to our hospital from January 2014 to May 2015 were collected, including of 120 cases postprandial distress syndrome （ PDS ） and 120 cases of epigastric pain syndrome （ EPS ） .According to the positive expression of Hp, the patients were divided into three groups： triple therapy group, sequential therapy group and control group, 80 eases in each group.The efficacies of FD treatment in each group were compared, and the correlation between Hp infection and FD treatment was explored. Result： The Hp detection rate of epigastric pain syndrome group was higher than that of postprandial distress syndrome group, the difference was statistically significant （ P〈0.05 ） . Two subtypes of functional dyspepsia patients after treatment of the three groups were better than those before treatment, the differences were statistically significant （P〈0.05） .Two subtypes of functional dyspepsia patients with symptoms of the sequential therapy group improved significantly better than those in triple therapy group, the symptom improvement of triple therapy group was better than that of the control group, the differences were statistically significant （ P〈0.05 ） .The total effective rate of the two subtypes of patients in sequential therapy group was significantly better than that in triple therapy group, the total effective rate of triple therapy group was better than that of the control group, the differences were statistically significant （ P〈0.05 ） .The Hp clearance rate of two subtypes of functional dyspepsia patients in sequential therapy group was significantly better than that of triple therapy group, the Hp clearance rate of triple therapy group was better than that of the control group, the differences were statistically significant （P〈0.05） .Conclusion： Different types of function

关 键 词：幽门螺杆菌 上消化道出血症状 上腹疼痛综合征 餐后不适综合征 

分 类 号：R57[医药卫生—消化系统]