进展期乳腺癌术后多西他赛联合卡培他滨化疗同步放疗的临床研究  

Clinical study of advancedbreastcancer postoperative of docetaxel combined with capecitabine chemotherapy concurrent with radiotherapy

作　　者：王轶珊[1] 李云霞[1] 田青[1] 毕清[1] 

机构地区：[1]昆明医科大学第三附属医院云南省肿瘤医院肿瘤内科,昆明650108

出　　处：《中国医学前沿杂志（电子版）》2017年第2期72-75,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：云南省教育厅科学研究基金项目(2014CD41Y)

摘　　要：目的探讨进展期乳腺癌术后多西他赛联合卡培他滨化疗同步放疗的临床效果。方法将本院2011年1月至2015年1月收治的进展期乳腺癌术后患者82例随机分为观察组与对照组,每组各41例。观察组患者采用多西他赛联合卡培他滨化疗同步放疗,对照组患者仅采用化疗治疗。比较两组患者近期疗效、随访1年和2年后生存和复发情况及不良反应发生情况。结果观察组患者治疗总有效率显著高于对照组(P<0.05)。随访1年,两组患者生存率比较无显著差异(P>0.05);随访2年,观察组患者生存率高于对照组(P<0.05)。随访1年和2年,观察组患者复发率均显著低于对照组(P<0.05)。两组患者胃肠道反应、骨髓抑制、肝功能异常及白细胞减少不良反应发生率比较均无显著差异(P>0.05)。结论进展期乳腺癌术后多西他赛联合卡培他滨化疗同步放疗可延长患者生存时间,降低复发率,近期疗效显著,具有重要的研究意义。Objective To explore the clinical effect of docetaxel combined with capecitabine chemotherapy in patients with advanced breast cancer after concurrent radiotherapy. Method 82 cases of advanced breast cancer patients admitted to our hospital from January 2011 to January 2015 were randomly divided into observation group and control group, 41 cases in each group. Observation group patients were treated by docetaxel combined with capecitabine chemotherapy concurrent with radiotherapy, while control group patients only received chemotherapy treatment. Compared the short-term efficacy, follow-up of 1 year and 2 years of survival and recurrence, and adverse reactions occurred between the two groups. Result The total effective rate of observation group was significantly higher than that of control group （P 〈 0.05）. After 1 year of follow-up, there was no significant difference in survival rate between the two groups （P 〉 0.05）. After 2 years of follow-up, the survival rate of observation group was higher than that of control group （P 〈 0.05）. Followed up for 1 year and 2 years, the recurrence rate of observation group were significantly lower than that of control group （P 〈 0.05）. There were no significant differences in the incidence of gastrointestinal reactions, bone marrow suppression, abnormal liver function and reduction of white blood cells in the two groups （P 〉 0.05）. Conclusion The short-term efficacy of docetaxel combined with capecitabine chemotherapy concurrent with radiotherapy in patients with advanced breast cancer is significant, which can prolong the survival time and reduce the recurrence rate.

关 键 词：进展期乳腺癌 多西他赛 卡培他滨 同步放疗 

分 类 号：R737.9[医药卫生—肿瘤]