内皮型一氧化氮合酶基因+894G/T多态性与偏头痛发病的meta分析  

Endothelial nitric oxide synthase(+894G/T) polymorphism and migraine susceptibility: a meta-analysis

作　　者：蕫晗 国琦[2] 郭志恒[3] 王哲[1] 刘松岩[2] 

机构地区：[1]吉林大学第一医院老年病科,吉林长春130021 [2]吉林大学中日联谊医院神经内科,吉林长春130033 [3]吉林大学第一医院产科,吉林长春130021

出　　处：《中风与神经疾病杂志》2017年第3期254-257,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的分析内皮型一氧化氮合酶(endothelial nitric oxide synthase,eNOS)基因+894G/T多态性与偏头痛发病风险之间的相关性。方法本研究检索时间从建库至2016年10月。纳入评估eNOS多态性(+894G/T)与偏头痛发病风险之间相关性的病例对照研究。初筛得到365篇全文,经筛选后最终5篇纳入meta分析。异质性分析采用I^2检验,文献质量评估采用英国牛津循证医学中心文献严格评价项目。结果与GG+GT基因型相比,TT基因型增加有先兆偏头痛(migraine with aura,MA)的发生风险(OR=1.56,95%CI 1.11~2.20;I^2=0%,P=0.01)。在非高加索人群中,GT+TT基因型可增加偏头痛发病风险(OR=1.53,95%CI 1.08~2.16;I^2=0%,P=0.02)。结论本研究提示内皮型一氧化氮合酶基因+894G/T多态性与偏头痛发病风险之间有一定的关系,并且可能因人群遗传背景的不同与偏头痛亚型有一定关联。Objective Aims： To evaluate the correlations between endothelial nitric oxide synthase（ eNOS） polymorphism（ ＋ 894G/T） and the risk of migraine. Methods A literature search was performed for case-control studies focusing on eNOS polymorphism（ ＋ 894G/T） and risk of migraine through October 2016. From 395 full-text articles,5 were included in this study. Heterogeneity was assessed with the I-2 index and quality assessment was performed using Oxford critical appraisal skill program. Results Compared with GG ＋ GT genotypes,TT genotype was associated with migraine with aura（ OR = 1. 56,95% CI 1. 11 - 2. 20; I2= 0%,P = 0. 01）. In non-Caucasian population,GT ＋ TT genotypes increased migraine susceptibility compared with GG genotype（ OR = 1. 53,95% CI 1. 08 -2. 16; I2= 0%,P = 0. 75）. Conclusion This meta-analysis indicated a linkage between eNOS polymorphism（ ＋ 894G/T） and the risk of migraine,which may be associated with enthicity and migraine subtypes.

关 键 词：内皮型一氧化氮合酶 基因多态性 偏头痛 易感性 

分 类 号：R747.2[医药卫生—神经病学与精神病学]