婴儿胆汁淤积性肝病的肝功能评估及价值  

The evaluation of liver function indices in infantile cholestatic hepatopathy

作　　者：陈源[1] 马雪玲[1] 马素苓[1] 耿江辉[1] 张少丹[1] 

机构地区：[1]河北医科大学第二医院儿科,河北石家庄050000

出　　处：《河北医科大学学报》2017年第3期293-296,共4页Journal of Hebei Medical University

摘　　要：目的分析婴儿胆汁淤积性肝病(infantile cholestatic hepatopathy,ICH)患儿肝功能指标的改变,探讨肝功能指标对ICH的诊断和预后评估的意义。方法选择在河北医科大学第二医院儿科住院治疗的86例ICH患儿的临床资料,回顾性分析患儿的病因学及治疗前后的肝功能指标,讨论肝功能指标对ICH诊断和预后的影响。结果巨细胞病毒感染性肝炎和胆道闭锁是ICH的最主要病因,巨细胞病毒感染性肝炎和胆道闭锁患儿血清γ谷胺酰转移酶(γ-glutamyl transferase,γ-GGT)、总胆汁酸(total bilea cids,TBA)水平在治疗前差异即有统计学意义(P<0.05)。对于胆道闭锁患儿,血清总胆红素对TBA影响最大。结论婴儿期ICH的肝功能各项指标,尤其是血清GGT、TBA水平,对ICH的诊断及预后评估有重要意义。Objective To study the changes of liver function indices at initial phase and post treatment in infantile cholestatic hepatopathy（ICH） patients, and then to analyze the prognostic value of liver function indices to ICH. Methods The conditions of 86 infants with ICH were reviewed from pediatric department in the Second Hospital of Hebei Medical University. Serum liver function parameters were analyzed retrospectively to evaluate the diagnostic and prognostic significance of ICH. Results Cytomegalovirus hepatitis and biliary atresia are the most main causes of ICH. The serum alanine aminotransferase levels of human cytomegalovirus hepatitis group and biliary atresia group at initial phase show no significant difference, while the serum 7- glutamyl transferase（7-GGT） and total bilea cids（TBA） levels of these groups are statistically significant from the other. As to biliary atresia patients, serum total bilirubin affects TBA significantly. Conclusion It is of great significance in serum liver function evaluation, especially serum 7-GGT and TBA levels in the diagnosis and the prognosis of patients with ICH.

关 键 词：胆汁淤积 肝内 婴儿 巨细胞病毒 

分 类 号：R575[医药卫生—消化系统]