ARHGAP4在结直肠癌中的表达及临床意义  

Expression and clinical significance of ARHGAP4 in colorectal cancer

作　　者：徐学虎[1] 徐远东[1] 祝梓原 黎淑玲[1] 吴小兵[1] 刘学娟[1] 

机构地区：[1]广州医科大学附属第三医院胃肠外科,510150

出　　处：《实用医学杂志》2017年第5期705-708,共4页The Journal of Practical Medicine

基　　金：广东省科技厅产学研协同创新成果转化项目(编号:2016B090918130)

摘　　要：目的:研究ARHGAP4基因在结直肠癌中的表达及临床意义。方法:采用RT-PCR、Western blot及免疫组化分析ARHGAP4基因在结直肠癌组织及细胞系中的表达水平,分析其表达与临床病理特征的相关性。结果:ARHGAP基因在结直肠癌组织及结直肠癌细胞系中的表达较癌旁正常组织及正常结肠上皮细胞明显升高。其蛋白表达水平与肿瘤的T分类,N分类,远处转移及生存时间密切相关(P<0.05)。结论:ARHGAP4过表达可能促进结直肠癌的发生、发展,具有作为结直肠癌预后判断标记物的潜能。Objective To study the expression and clinical significance of ARHGAP4 in colorectal cancer Method Real- time PCR, Western blot and immunocytochemistry were used to detect the expression of ARHGAP4 in colorectal cancer tissues and cell lines, and the correlation between its expression and clinical features of patients was analyzed Results ARHGAP4 is overexpressed in colorectal cancer tissues and cell lines and its overexpression is correlated with T stage, N stage, clinical stage, and metastasis. Conclusion ARHGAP4 may promote the progression of colorectal cancer, and have the potential to be a novel prognosis marker .

关 键 词：结直肠肿瘤 ARHGAP4 临床意义 

分 类 号：R735.34[医药卫生—肿瘤]