Stat5在甲状腺癌中的表达及其与上皮间质转化的关系  

Expression of Stat5 in thyroid carcinoma and its relationship with EMT

作　　者：薛云 李道明 张静 黄培 尹玉慧 

机构地区：[1]郑州大学第一附属医院病理科,郑州大学基础医学院病理学系与河南省肿瘤病理重点实验室,450052

出　　处：《实用医学杂志》2017年第6期905-908,共4页The Journal of Practical Medicine

基　　金：河南省科学技术厅项目(编号:142300410215)

摘　　要：目的:研究信号转导和转录活化因子5(Stat5)和上皮间质转化(EMT)标志物E-cadherin、Vimen-tin在甲状腺癌中的表达及相关性分析。方法:采用免疫组织化学SP法检测149例甲状腺石蜡标本(包括甲状腺癌126例和结节性甲状腺肿23例)中Stat5、E-cadherin、Vimentin的表达,并结合主要临床病理参数进行相关分析。结果:Stat5、Vimentin在甲状腺癌组织中的阳性率分别为85.71%、77.78%,明显高于结节性甲状腺肿中的阳性率26.09%、8.70%(P<0.05),甲状腺癌组织中E-cadherin的阳性率为25.40%,低于结节性甲状腺肿中的阳性率86.96%(P<0.05);3种蛋白的表达与性别、年龄无明显相关性(P>0.05),而与淋巴结转移、病理分型相关(P<0.05);Stat5和E-cadherin的表达呈负相关(r=-0.335,P=0.000),Stat5与Vimenin的表达呈正相关(r=0.218,P<0.05)。结论:甲状腺癌组织中存在Stat5高表达及EMT,提示Stat5可能参与了甲状腺癌的EMT过程,从而促进甲状腺癌的侵袭转移。Objective To study the expression of Stat5, E-cadherin and Vimentin in thyroid carcinoma and the correlation among them. Method The expression of Stat5, E-cadherin and Vimentin in 149 cases of thyroid specimens （including 23 cases of nodular goiter and 126 cases of thyroid carcinoma） was detected by immunohisto- chemistry SP method and the correlation analysis was conducted with the main clinical pathological parameters. Results The positive rate of Stat5 and Vimentin in thyroid carcinoma was 85.71% and 77.78% respectively, which was significantly higher than that in nodular goiter （26.09% and 8.70% ） （P 〈 0.05 ） and the positive rate of E-cadherin in thyroid carcinoma was 25.40%, lower than that in nodular goiter （86.96%） （P 〈 0.05）. Three kinds of protein expression were not significantly correlated with gender and age （P 〉 0.05）, but obviously with lymph node metastasis and pathological type （P 〈 0.05 ）. Stat5 was negatively correlated with the expression of E-cadherin （r = -0.335, P = 0.000） but positively with the expression of Vimentin （r = 0.218, P 〈 0.05）. Conclusion The high expression of Star5 and EMT in thyroid carcinoma tissues indicate that Stat5 may be involved in the EMT process of thyroid carcinoma, thus it can promote the invasion and metastasis of thyroid carcinoma.

关 键 词：甲状腺肿瘤 信号转导和转录活化因子5 上皮间质转化 E-CADHERIN VIMENTIN 

分 类 号：R736.1[医药卫生—肿瘤]