左旋门冬氨酸鸟氨酸联合乳果糖治疗肝硬化肝性脑病的疗效观察  

Therapeutic Effect of Levorotatory Aspartic Acid-ornithine Combined with Lactulose on Hepatocirrhosis Complicated with Hepatic Encephalopathy

作　　者：陈茹[1] 宋树芬[1] 刘涛[1] 

机构地区：[1]山东青岛市传染病医院,山东青岛266033

出　　处：《中国医药指南》2017年第9期5-6,共2页Guide of China Medicine

摘　　要：目的观察左旋门冬氨酸鸟氨酸联合乳果糖治疗肝硬化合并肝性脑病的临床疗效以及安全性。方法 88例肝硬化合并肝性脑病患者随机分为治疗组和对照组,治疗组46例,综合治疗基础上给予左旋门冬氨酸鸟氨酸联合乳果糖,对照组42例,综合治疗基础上给予乙酰谷酰胺,疗程为7 d,观察患者肝性脑病改善情况。结果治疗组患者治疗后1 d、3 d和7 d时清醒率分别为65.22%、73.91%和84.78%、血氨降低明显高于对照组,有显著性差异(P<0.05或P<0.01)。结论左旋门冬氨酸鸟氨酸联合乳果糖治疗肝硬化合并肝性脑病能快速降低血氨,促进肝性脑病患者的清醒,是值得在临床中推广应用的治疗方法。Objective To observe the efficacy and safety of levorotatory aspartic acid-omithine combined with lactulose on hepatocirrhosis complicated with hepatic encephalopathy. Methods Eighty-eight patients of hepatocirrhosis complicated with hepatic encephalopathy were divided into therapy group （n=46） and control group （n=42）. Both two groups were treated with routine complex treatment, and those in the therapy group received additional levorotatory aspartic acid-ornithine combined with lactulose, those in the control group received additional acetylglutamide, 7 days for a treatment course, tO observe improvement of hepatic encephalopathy. Results Conscious rate of patients in the therapy group is 65.22%, 73.91% and 84.78% respectively after one day, three days and seven days of treatment. The decrease of blood ammonia was significantly higher than that of control group（P〈0.05）. Conelnslon Combined application of levorotatory aspartic acid-ornithine and lactulose on hepatocirrhosis complicated with hepatic encephalopathy can reduce blood ammonia quickly, and promote conscious of patients with hepatic encephalopathy. It is a method which is worthy of clinical application.

关 键 词：左旋门冬氨酸鸟氨酸 乳果糖 联合治疗 肝硬化 肝性脑病 

分 类 号：R575.2[医药卫生—消化系统]