烷(芳)基重氮化合物与酮(醛、亚胺)插入反应的研究进展  

Research Progress on the Insertion Reaction of Ketones (Aldehydes or Imine) with Alkyl-or Aryldiazomethanes

作　　者：康泰然[1] 赵娟[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637009

出　　处：《西华师范大学学报（自然科学版）》2017年第1期6-13,共8页Journal of China West Normal University(Natural Sciences)

基　　金：国家自然科学基金项目(21672172);四川省教育厅重大培育项目(15CZ0016);生物医用新材料四川省青年科技创新研究团队(2017TD0008)

摘　　要：烷(芳)基重氮化合物不稳定,在实验室里难以分离提纯和保存,这些不利因素影响了其应用研究。近年来,采用原位制备烷(芳)基重氮化合物方法拓展了其在有机合成中的应用。本文综述了原位制备的烷(芳)基重氮化合物与醛、酮和亚胺发生插入反应的研究进展。重点介绍了烷(芳)基重氮化合物与酮(非环状酮、单环状酮和桥环酮等)发生插入反应的一些研究进展。The research on the application of Diazoalkanes and arylsubstituted diazomethane derivatives is greatly hindered by its instability that leads to the difficulty of its separation,purification and preservation in the laboratory.In recent years,its application in organic synthesis has been greatly expanded by the method of generating Diazo compounds in situ. This paper gives a summary of the research progress on the insertion reactions of alkyl or aryl diazo compounds formed in situ been added to ketones,aldehydes and imine. More emphasis is put on the research progress of insertion reactions coming from the addition of diazo compounds to acyclic ketones,cyclic ketones and bridged cyclic ketones.

关 键 词：烷(芳)基重氮甲烷 羰基化合物 亚胺 碳链增长 扩环反应 

分 类 号：O472[理学—半导体物理] O484[理学—物理]