他达那非治疗直肠癌术后勃起功能障碍的疗效观察  

Efficacy of Tadalafil in the Treatment of Erectile Dysfunction After Rectal Cancer Surgery

作　　者：李明[1] 寇卫军[1] 周亮[1] 王少强[1] 张卫国[1] 寇明文[1] 饶德新 张文博[1] 

机构地区：[1]解放军第155中心医院普通外科,河南开封475003

出　　处：《临床医学工程》2017年第4期529-530,共2页Clinical Medicine & Engineering

摘　　要：目的探讨他达那非治疗直肠癌术后勃起功能障碍(ED)的疗效。方法 11例直肠癌术后ED患者依据直肠癌术后时间分为两组,A组为3~12个月组,B组为>12个月组。每天给予5 mg他达那非连续治疗12周,应用IIEF-5评分和"性活动日志"(SEP)评估疗效。结果 9例患者完成研究,两组均对直肠癌术后ED有一定的疗效。A组SEP1、SEP2和SEP5平均阳性回答率均显著高于B组(均P<0.05);12周后,A组的IIEF-5评分增加值显著高于B组(P<0.05)。结论他达那非对直肠癌术后ED有较好的治疗作用,直肠癌术后越早使用其疗效越好。Objective To explore the efficacy of tadalafil in the treatment of erectile dysfunction（ED） after rectal cancer surgery.Methods 11 cases of patients with ED after rectal cancer surgery were selected. According to the duration after surgery,all cases were divided into group A（within 3 to 12 months after surgery） and group B（over 12 months after surgery）. All patients received 5 mg of tadalafil daily for 12 weeks,and IIEF-5 score and sexual encounter profile（SEP） were used to evaluate the efficacy. Results 9 patients completed the study. Both groups had certain efficacy for ED after rectal cancer surgery. The average positive response rates of SEP1,SEP2 and SEP5 of group A were significantly higher than those of group B（P〈0.05）. 12 weeks later,the added value of IIEF-5 of group A was significantly higher than that of group B（P〈0.05）. Conclusions Tadalafil has better curative effect for patients with ED after rectal cancer surgery.Earlier use of tadalafil after rectal cancer surgery will get better efficacy.

关 键 词：直肠癌手术 勃起功能障碍 他达那非 疗效 

分 类 号：R735.31[医药卫生—肿瘤]