血管内皮细胞生长因子、基质金属蛋白酶-2和基质金属蛋白酶抑制因子-2在非小细胞肺癌中的表达及意义  

Expression of vascular endothelial growth factor, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in non small cell lung carcinoma and its clinical significance

作　　者：余雪君[1] 刘欣艳[1] 李彩荣[1] 王锦俊 赵纯诚 盛霞[3] 陶玙婧[1] 

机构地区：[1]上海市普陀区中心医院老年科,上海200062 [2]上海市普陀区中心医院胸外科,上海200062 [3]上海市普陀区中心医院病理科,上海200062

出　　处：《中国医药导报》2017年第8期107-110,共4页China Medical Herald

摘　　要：目的探讨非小细胞肺癌(NSCLC)组织中血管内皮细胞生长因子(VEGF)、基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶抑制因子-2(TIMP-2)的表达与肺癌侵袭和转移的关系。方法收集上海市普陀区中心医院2012年1月~2015年12月临床和病理确诊的56例NSCLC标本,其中25例肺鳞癌、31例肺腺癌;另取20例癌旁正常肺组织作为阴性对照,用免疫组化SP法检测标本中VEGF、MMP-2和TIMP-2的表达。结果 VEGF、MMP-2和TIMP-2在肺癌和正常肺组织中的表达差异有统计学意义(P<0.05);VEGF和MMP-2的表达与肺癌淋巴结转移和临床分期呈正相关(P<0.05),TIMP-2的表达与肺癌淋巴结转移和临床分期呈负相关(P<0.05),但都与病理类型无关(P>0.05)。结论 VEGF、MMP-2和TIMP-2的表达与非小细胞肺癌的侵袭和转移相关,可作为评价肺癌组织侵袭和转移能力的指标。Objective To study the expression of vascular endothelial growth factor（VEGF）, matrix metalloproteinase-2（MMP-2） and tissue inhibitor of metalloproteinase-2（TIMP-2） in non small cell lung carcinoma（NSCLC） and their relationship with invasion and metastasis of the lung cancerous tissues. Methods Fifty-six cases of human NSCLC tissues which had clinical and pathological diagnosis were collected from the Central Hospital of Shanghai Putuo District from January 2012 to December 2015. Among them, 25 cases had lung squamous cell carcinoma and 31 cases had lung adenocarcinoma. Another 20 cases of adjacent normal lung tissue were taken as a negative control. The expression of VEGF, MMP-2 and TIMP-2 were detected by SP immunohistochemical technique in all specimens. Results The expression of VEGF, MMP-2 and TIMP-2 in lung carcinoma and normal lung tissues were statistically significantly different（P 〈 0.05）. There were positive correlations between the expression of VEGF and MMP-2 with lymph node metastasis and clinical stage（P 〈 0.05）, but there was negative correlation between the expression of TIMP-2 with lymph node metastasis and clinical stage respectively（P 〈 0.05）. The expression of VEGF, MMP-2 and TIMP-2 had no association with pathological type（P 〉 0.05）. Conclusion The expression of VEGF, MMP-2 and TIMP-2 are associated with the invasion and metastasis in lung carcinoma, which may be potentially useful for indicating the metastasis and invasion of lung carcinoma.

关 键 词：非小细胞肺癌 血管内皮细胞生长因子 基质金属蛋白酶-2 基质金属蛋白酶抑制因子-2 免疫组织化学 肿瘤转移 

分 类 号：R734.2[医药卫生—肿瘤]