VEGF、VEGFR-1和MMP-9对良恶性胸腔积液的诊断价值  

The Diagnostic Value of VEGF,VEGFR-1 and MMP-9 in Malignant/benign Pleural Effusion

作　　者：赵斌斌 李云霞 扁长萍 朱运奎[2] 

机构地区：[1]甘肃省平凉市人民医院,744000 [2]解放军兰州军区总医院,730000

出　　处：《实用癌症杂志》2017年第4期690-692,共3页The Practical Journal of Cancer

摘　　要：目的探讨血管内皮生长因子(VEGF)、受体VEGFR-1和基质金属蛋白酶-9(MMP-9)表达在良、恶性胸腔积液鉴别诊断中的价值。方法采用ELISA法,检测35例恶性胸腔积液、33例良性胸腔积液患者胸腔积液中VEGF,VEGFR-1和MMP-9表达水平,并进行相关性比较分析。结果恶性胸腔积液组中VEGF、VEGFR-1表达均明显高于良性胸腔积液,MMP-9表达明显低于良性胸腔积液,差异均有统计学意义(P<0.05)。恶性胸腔积液中VEGF,VEGFR-1和MMP-9表达水平呈正相关。VEGF,VEGFR-1和MMP-9与恶性胸腔积液的病理类型无相关性。结论胸腔积液中VEGF,VEGFR-1和MMP-9表达可以作为良性和恶性胸腔积液鉴别诊断的标志物。Objective To investigate the value of vascular endothelial growth factor（ VEGF）, its soluble receptor VEG- FR-1 and matrix metalloproteinase-9 （MMP-9） in differentiating benign from malignant pleural effusion. Methods Using ELISA, the levels of VEGF,VEGFR-land MMP-9 in pleural effusion in 35 patients with malignant pleural effusion and 33 with benign pleural effusion were detected and compared. Results The VEGF, VEGFR-1 levels in malignant pleural fluid were markedly higher than those in benign pleural effusion, the MMP-9 levels in malignant pleural fluid were markedly lower than those in benign pleural effusion with a significant difference among VEGF, VEGFR-1 and MMP-9 （ P 〈 0.05 ）. In the pleural fluids, the values VEGF,VEGFR-1 and MMP-9 were significantly related to each other（P 〈 0.05 ）. There was no significant association among VEGF, VEGFR-1 and MMP-9 in patients with pathological type. Conclusion The measurement of VEGF, VEGFR-1 and MMP-9 levels in the pleural effusion could be useful.

关 键 词：胸腔积液 恶性/良性 血管内皮生长因子 血管内皮生长因子受体-1 基质金属蛋白酶-9 

分 类 号：R734.2[医药卫生—肿瘤]