逍遥丸对肝气郁结型轻度认知功能障碍患者情绪和神经内分泌功能的影响  

Effect of Peripateticism pill on the mood and neuroendocrine function in MCI patients with liver qi stagnation

作　　者：侯俊林[1] 詹向红[1] 闫国立[1] 梁鹤[1] 刘永[1] 关徐涛[1] 孙前明[1] 李伟[1] 

机构地区：[1]河南中医药大学,河南郑州450046

出　　处：《中国老年学杂志》2017年第7期1642-1644,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金(81173148;81473556);河南中医药大学博士科研基金(BSJJ2011-08)

摘　　要：目的探讨逍遥丸对肝气郁结型轻度认知功能障碍(MCI)患者情绪状态、肝郁程度和神经内分泌功能的影响。方法用国际MCI诊断标准和肝气郁结证症状筛选标准筛选40~65岁的肝气郁结型MCI患者,用Beck抑郁量表(BDI)、Beck焦虑量表(BAI)、肝气郁结证症状程度计分表对肝气郁结型MCI患者的情绪状态、肝气郁结程度进行评测,用酶联免疫吸附法(ELISA)检测患者用药前后的促肾上腺皮质激素(ACTH)、肾上腺糖皮质激素(GC)和去甲肾上腺素(NE)水平。结果与用药前相比,患者用药后的BDI、BAI、肝气郁结证症状程度计分降低(P<0.05),ACTH水平降低(P<0.05),NE水平升高(P<0.05),GC值无明显变化(P>0.05)。结论逍遥丸能够改善肝郁型MCI患者的抑郁、焦虑情绪和肝气郁结症状,ACTH浓度降低、NE浓度升高是其可能的原因。Objective To study the effect of Peripateticism pill on the mood,liver depression degree and neuroendocrine function in MCI patients with liver qi stagnation.Methods International diagnostic criteria for MCI and symptoms of liver qi stagnation screening standard were used to screen 40 ~ 65 years old MCI patients with liver qi stagnation. Beck Depression Inventory,Beck Anxiety Inventory and the degree of liver qi stagnation scores table were used to evaluate emotional state and the degree of liver qi stagnation. Enzyme-linked immunosorbent assay（ ELISA） was used to analyze adrenocorticotropic hormone（ ACTH）,glucocorticoid（ GC） and norepinephrine（ NE） in patients before and after treatment.Results Compared with before treatment,scores of BDI,BAI and symptoms of liver qi stagnation screening were all reduced（ P〈0.05）,ACTH was decreased（ P〈0.05）,NE was increased（ P〈0.05）,GC had no significant changes（ P〈0.05） after treatment.Conclusions Peripateticism pill could reduce depression,anxiety and symptoms of liver qi stagnation in MCI patients with liver qi stagnation. The possible reason is ACTH concentration decrease and NE concentration increase.

关 键 词：逍遥丸 肝气郁结 轻度认知功能障碍 

分 类 号：R741[医药卫生—神经病学与精神病学]