慢性酒精中毒引起的脑神经损害与Aβ蛋白变化的相关性  

Relationship between brain nerve damage caused by chronic alcohol poisoning and A beta protein

作　　者：樊雅青 徐国辉[1] 于浩[1] 张楚楠 张国华[1] 

机构地区：[1]中国医科大学法医学院,辽宁沈阳110122 [2]中国医科大学,辽宁沈阳110122

出　　处：《解剖科学进展》2017年第2期189-192,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81172904);辽宁省自然科学基金(201102299);沈阳市科技计划项目(F11-264-1-67)

摘　　要：慢性酒精中毒会对脑神经造成损伤,并且这种损伤与Aβ蛋白变化有着密切的关系。慢性酒精中毒会促进Aβ蛋白的产生,而Aβ蛋白可以激活星形胶质细胞和小神经胶质细胞,产生过多的炎症细胞因子间接损害神经,亦可通过影响线粒体的功能而损害神经元。Aβ蛋白对脑神经的损伤可表现为认知、记忆功能障碍,引发阿尔兹海默病(AD)。Chronic alcohol poisoning often caused brain nerve damage which is related intimately to A beta protein. Chronic alcohol poisoning promoted the production of A beta protein which activated astrocytes and microglia, resulting in excessive inflammatory cytokines to damage nerves indirectly, and also damage neurons by affecting mitochondrial function. Brain nerve damage caused by A beta protein would further lead to dysfunction of cognition and memory, and Alzheimer＇s disease （AD）.

关 键 词：AΒ蛋白 慢性酒精中毒 脑神经损害 阿尔兹海默病 神经胶质细胞 炎症细胞因子 记忆功能障碍 淀粉样前体蛋白 氧化应激 脑片 

分 类 号：R749.16[医药卫生—神经病学与精神病学]